Guoyin Li, Zewen Song, Yi Ru, Jing Zhang, Lianxiang Luo, Wei Yang, Hao Wu, Haibao Jin, Xuanwen Bao, Di Wei, Zhao Yan, Haijing Qu, Zheng Zhu, Gang Zhou
{"title":"内封底:具有高药物负载和EGFR、PI3K/AKT双重抑制特性的小分子纳米前药,用于膀胱癌症治疗(EXP2 5/2023)","authors":"Guoyin Li, Zewen Song, Yi Ru, Jing Zhang, Lianxiang Luo, Wei Yang, Hao Wu, Haibao Jin, Xuanwen Bao, Di Wei, Zhao Yan, Haijing Qu, Zheng Zhu, Gang Zhou","doi":"10.1002/EXP.20230503","DOIUrl":null,"url":null,"abstract":"<p>Overexpression of the EGFR is found in up to 74% of bladder cancer tissue. Two natural products that were found, triptolide (represented by lightning) and hesperidin (represented by orange), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles (represented by oranges containing lightning), which not only remarkably improved their bioavailability and therapeutic but also reduced their systemic toxicity.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"3 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230503","citationCount":"0","resultStr":"{\"title\":\"Inside Back Cover: Small-molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual-inhibiting properties for bladder cancer treatment (EXP2 5/2023)\",\"authors\":\"Guoyin Li, Zewen Song, Yi Ru, Jing Zhang, Lianxiang Luo, Wei Yang, Hao Wu, Haibao Jin, Xuanwen Bao, Di Wei, Zhao Yan, Haijing Qu, Zheng Zhu, Gang Zhou\",\"doi\":\"10.1002/EXP.20230503\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Overexpression of the EGFR is found in up to 74% of bladder cancer tissue. Two natural products that were found, triptolide (represented by lightning) and hesperidin (represented by orange), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles (represented by oranges containing lightning), which not only remarkably improved their bioavailability and therapeutic but also reduced their systemic toxicity.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":72997,\"journal\":{\"name\":\"Exploration (Beijing, China)\",\"volume\":\"3 5\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230503\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Exploration (Beijing, China)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/EXP.20230503\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration (Beijing, China)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/EXP.20230503","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Inside Back Cover: Small-molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual-inhibiting properties for bladder cancer treatment (EXP2 5/2023)
Overexpression of the EGFR is found in up to 74% of bladder cancer tissue. Two natural products that were found, triptolide (represented by lightning) and hesperidin (represented by orange), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles (represented by oranges containing lightning), which not only remarkably improved their bioavailability and therapeutic but also reduced their systemic toxicity.