TRIM7的反铁作用：分子机制及与替莫唑胺的协同作用

Cancer Innovation Pub Date : 2023-05-15 DOI:10.1002/cai2.77

Luyao Wang, Rongyang Xu, Chengying Huang, Shanqiang Qu

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引用次数: 0

摘要

核受体共激活因子4（NCOA4）蛋白是一种选择性货物受体，通过靶向铁蛋白-铁储存蛋白并将其递送至溶酶体进行降解和释放铁，在铁蛋白吞噬中发挥关键作用。TRIM7过表达通过泛素化NCOA4蛋白抑制胶质母细胞瘤细胞中的脱铁性贫血。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide

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The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide

Nuclear receptor coactivator 4 (NCOA4) protein is a selective cargo receptor that plays a crucial role in ferritinophagy by targeting and delivering the ferritin iron storage protein to lysosomes for degradation and releasing iron. TRIM7 overexpression inhibits ferroptosis in glioblastoma cells by ubiquitinating NCOA4 protein.

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来源期刊

Cancer Innovation

CiteScore

0.70

自引率

0.00%

发文量