Elizabeth Pérez-Cruz , Irving Horacio Torres-López
{"title":"重度肥胖患者接受和未接受胃分流术的维生素D和甲状旁腺激素水平","authors":"Elizabeth Pérez-Cruz , Irving Horacio Torres-López","doi":"10.1016/j.nupar.2023.05.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>To determine the status of 25(OH)D and parathyroid hormone (PTH) levels in patients with severe obesity who undergo and not undergo gastric bypass (GB); and analyzed their correlation with the degree of obesity and fat mass.</p></div><div><h3>Methods</h3><p>Cross-sectional study in 34 patients, analyzed in two groups: a) patients who not undergo GB and b) patients who did undergo GB. Height, weight, BMI, body composition, % excess weight loss (EWL) and % total weight loss (TWL) were determinate. 25(OH)D level was categorized according to the Endocrine Society criteria.</p></div><div><h3>Results</h3><p>Mean age was of 37.24<!--> <!-->±<!--> <!-->5.83 vs 40.82<!--> <!-->±<!--> <!-->9.03<!--> <!-->years (<em>P</em> <!-->=<!--> <!-->0.021) and BMI of 44.92<!--> <!-->±<!--> <!-->8.63 vs 31.28<!--> <!-->±<!--> <!-->5.60<!--> <!-->kg/m<sup>2</sup> (<em>P</em> <!-->=<!--> <!-->0.001) in patients who did not undergo GB and underwent GB respectively. Patients who underwent GB showed decreased levels of 25(OH)D: 14.04<!--> <!-->±<!--> <!-->10.42<!--> <!-->ng/mL vs patients without surgery 31.95<!--> <!-->±<!--> <!-->31.00<!--> <!-->ng/mL (<em>P</em> <!--><<!--> <!-->0.001). Vitamin D deficiency was identified in 70% patients having GB vs 59% patients without surgery (<em>P</em> <!--><<!--> <!-->0.05). Of all patients with GB, 35% were diagnosed with hyperparathyroidism vs 29% of those without GB (<em>P</em> <!-->=<!--> <!-->0.492). Serum 25(OH)D concentrations were disclosed a significant inverse relationship with the % TWL after surgery, but not with weight, BMI and fat mass.</p></div><div><h3>Conclusions</h3><p>Vitamin D deficiency is prevalent in patients with severe obesity and patients who did undergo GB. The major determinant of low levels of 25(OH)D was % TWL after surgery. Hyperparathyroidism did not indicate vitamin D deficiency.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Pages 176-180"},"PeriodicalIF":0.5000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Vitamin D status and parathyroid hormone in patients with severe obesity who undergo and not undergo gastric bypass\",\"authors\":\"Elizabeth Pérez-Cruz , Irving Horacio Torres-López\",\"doi\":\"10.1016/j.nupar.2023.05.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><p>To determine the status of 25(OH)D and parathyroid hormone (PTH) levels in patients with severe obesity who undergo and not undergo gastric bypass (GB); and analyzed their correlation with the degree of obesity and fat mass.</p></div><div><h3>Methods</h3><p>Cross-sectional study in 34 patients, analyzed in two groups: a) patients who not undergo GB and b) patients who did undergo GB. Height, weight, BMI, body composition, % excess weight loss (EWL) and % total weight loss (TWL) were determinate. 25(OH)D level was categorized according to the Endocrine Society criteria.</p></div><div><h3>Results</h3><p>Mean age was of 37.24<!--> <!-->±<!--> <!-->5.83 vs 40.82<!--> <!-->±<!--> <!-->9.03<!--> <!-->years (<em>P</em> <!-->=<!--> <!-->0.021) and BMI of 44.92<!--> <!-->±<!--> <!-->8.63 vs 31.28<!--> <!-->±<!--> <!-->5.60<!--> <!-->kg/m<sup>2</sup> (<em>P</em> <!-->=<!--> <!-->0.001) in patients who did not undergo GB and underwent GB respectively. Patients who underwent GB showed decreased levels of 25(OH)D: 14.04<!--> <!-->±<!--> <!-->10.42<!--> <!-->ng/mL vs patients without surgery 31.95<!--> <!-->±<!--> <!-->31.00<!--> <!-->ng/mL (<em>P</em> <!--><<!--> <!-->0.001). Vitamin D deficiency was identified in 70% patients having GB vs 59% patients without surgery (<em>P</em> <!--><<!--> <!-->0.05). Of all patients with GB, 35% were diagnosed with hyperparathyroidism vs 29% of those without GB (<em>P</em> <!-->=<!--> <!-->0.492). Serum 25(OH)D concentrations were disclosed a significant inverse relationship with the % TWL after surgery, but not with weight, BMI and fat mass.</p></div><div><h3>Conclusions</h3><p>Vitamin D deficiency is prevalent in patients with severe obesity and patients who did undergo GB. The major determinant of low levels of 25(OH)D was % TWL after surgery. Hyperparathyroidism did not indicate vitamin D deficiency.</p></div>\",\"PeriodicalId\":54702,\"journal\":{\"name\":\"Nutrition Clinique et Metabolisme\",\"volume\":\"37 3\",\"pages\":\"Pages 176-180\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Clinique et Metabolisme\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0985056223002443\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Clinique et Metabolisme","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0985056223002443","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Vitamin D status and parathyroid hormone in patients with severe obesity who undergo and not undergo gastric bypass
Aim
To determine the status of 25(OH)D and parathyroid hormone (PTH) levels in patients with severe obesity who undergo and not undergo gastric bypass (GB); and analyzed their correlation with the degree of obesity and fat mass.
Methods
Cross-sectional study in 34 patients, analyzed in two groups: a) patients who not undergo GB and b) patients who did undergo GB. Height, weight, BMI, body composition, % excess weight loss (EWL) and % total weight loss (TWL) were determinate. 25(OH)D level was categorized according to the Endocrine Society criteria.
Results
Mean age was of 37.24 ± 5.83 vs 40.82 ± 9.03 years (P = 0.021) and BMI of 44.92 ± 8.63 vs 31.28 ± 5.60 kg/m2 (P = 0.001) in patients who did not undergo GB and underwent GB respectively. Patients who underwent GB showed decreased levels of 25(OH)D: 14.04 ± 10.42 ng/mL vs patients without surgery 31.95 ± 31.00 ng/mL (P < 0.001). Vitamin D deficiency was identified in 70% patients having GB vs 59% patients without surgery (P < 0.05). Of all patients with GB, 35% were diagnosed with hyperparathyroidism vs 29% of those without GB (P = 0.492). Serum 25(OH)D concentrations were disclosed a significant inverse relationship with the % TWL after surgery, but not with weight, BMI and fat mass.
Conclusions
Vitamin D deficiency is prevalent in patients with severe obesity and patients who did undergo GB. The major determinant of low levels of 25(OH)D was % TWL after surgery. Hyperparathyroidism did not indicate vitamin D deficiency.
期刊介绍：
Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.
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