利用连续Kornblum和Kabachnik-fields反应，超声波辅助合成了卤苄酯类α-氨基膦酸盐

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI:10.1080/10426507.2022.2157830

Rabia Amin , Tabassum Ara

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引用次数: 0

摘要

通过Kornblum/Kabachnik场反应，开发了一种超声辅助合成α-氨基膦酸盐的简单、简便、直接的方法。该方法包括由苄基卤化物通过氧化脱卤原位生成醛中间体，然后在超声波照射下以一锅三组分方式与芳基胺和亚磷酸三烷基酯偶联。所开发的方法与各种功能相容，并且在温和的条件下以良好至优异的产率获得所需的产物。

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An ultra-sound assisted synthesis of α-aminophosphonates from benzyl halides via sequential Kornblum and Kabachnik-fields reaction

An ultrasound-assisted simple, easy and straightforward method for the synthesis of α-aminophosphonates has been developed via Kornblum/Kabachnik-fields reaction. The method involves in situ generation of an aldehyde intermediate from benzyl halides via oxidative dehalogenation followed by coupling with aryl amine and trialkyl phosphite in a one-pot three component manner under ultrasonic irradiations. The developed method is compatible with various functionalities and the desired products are obtained in good to excellent yield under mild conditions.

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来源期刊

Phosphorus, Sulfur, and Silicon and the Related Elements 化学-无机化学与核化学

CiteScore

2.60

自引率

7.70%

发文量

103

审稿时长

2.1 months

期刊介绍： Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.