代谢健康型和不健康型肥胖成人的健康饮食指数和骨骼健康指标

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Lara Gomes Suhett , May Cheung , Rosemary DeLuccia Dall , Deeptha Sukumar
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引用次数: 0

摘要

健康饮食指数(HEI)评估饮食质量,低HEI评分与不良的骨骼预后相关。然而,HEI评分与肥胖但其他方面健康或肥胖合并合并症的个体骨骼健康之间的关系尚不清楚。目的探讨代谢健康型肥胖(MHO)和代谢不健康型肥胖(MUO)患者HEI评分与骨密度(BMD)、骨调节激素和骨转换标志物的关系。方法对122名超重或肥胖的成年人进行横断面分析。完成一份调查问卷以获得人口统计数据。通过双能x线吸收仪(DXA)检查评估体成分和骨密度。采用24小时膳食召回法计算HEI评分和膳食成分。采集血样分析血清25-羟基维生素D (s25OHD)、总骨钙素(OC)、甲状旁腺激素(PTH)和c端端肽(CTx)浓度。MHO和MUO表型根据有无代谢异常进行分类。结果样本平均年龄37.91±12.66岁,男性占50.8%,平均体重指数(BMI)为30.01±4.63 kg/m2, 45.9%为MUO表型。平均HEI评分为54.42±16.25,61.48%的患者饮食质量较差。MUO表型组HEI评分与s25OHD呈正相关(β = 0.194, 95%CI = 0.038 ~ 0.350, p = 0.016)。某些饮食评分成分,如水果、海鲜和植物蛋白、添加糖、全谷物和脂肪酸,也与骨骼健康指标有关。然而,HEI评分与骨密度测量无关,也与其他骨调节激素和转换标志物无关。结论超重或肥胖伴MUO表型的成人HEI评分与s25OHD呈正相关。此外,适当食用特定种类的食物可能有益于骨量和新陈代谢。这些结果强调了生活方式干预的重要性,鼓励健康的饮食习惯,以预防s25OHD缺乏,骨骼健康不良和心脏代谢并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Healthy eating index and bone health markers in adults with metabolically healthy and unhealthy obese phenotypes

Background

The Healthy Eating Index (HEI) estimates the diet quality, and low HEI scores are associated with adverse bone outcomes. However, the relationship between HEI scores and bone health in individuals who are obese but otherwise healthy or obese with comorbidities remains unclear.

Objective

We aimed to evaluate the association of HEI scores with bone mineral density (BMD), bone regulating hormones and bone turnover markers in individuals with metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) phenotypes.

Methods

This was a cross-sectional analysis of 122 adults who were overweight or obese. A questionnaire was completed to obtain demographic data. Body composition and BMD were assessed by a Dual Energy X-Ray Absorptiometry (DXA) exam. The HEI scores and dietary components were calculated using a 24-h dietary recall. Blood samples were collected for the analysis of serum 25-hydroxyvitamin D (s25OHD), total osteocalcin (OC), parathyroid hormone (PTH), and C-terminal telopeptide (CTx) concentrations. The MHO and MUO phenotypes were classified according to the absence or presence of metabolic abnormalities.

Results

The sample mean age was 37.91 ± 12.66 years, 50.8% were men, mean body mass index (BMI) was 30.01 ± 4.63 kg/m2, and 45.9% were classified as the MUO phenotype. The mean HEI scores were 54.42 ± 16.25 and 61.48% had low-diet quality. HEI scores were positively associated with s25OHD in the MUO phenotype group (β = 0.194, 95%CI = 0.038–0.350, p = 0.016). Certain dietary score components, such as fruits, seafood and plant protein, added sugars, whole grains, and fatty acids were also associated with bone health markers. However, HEI scores were not associated with BMD measures, neither with other bone regulating hormones and turnover markers.

Conclusion

There was a positive association between HEI scores and s25OHD in adults who were overweight or obese with MUO phenotype. Additionally, the adequate consumption of specific food groups may benefit bone mass and metabolism. These results emphasize the importance of lifestyle interventions encouraging healthy eating habits to prevent s25OHD deficiency, poor bone health, and cardiometabolic complications.

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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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