Resultados maternos y fetales en pacientes con preeclampsia severa e hipotiroidismo primario. Estudio de casos y controles

Introduction

Primary hypothyroidism has adverse effects on maternal and fetal outcomes. In the scenario of severe preeclampsia (SP), the impact on the binomial may be greater.

Objective

To compare maternal and fetal outcomes in patients with SP and primary hypothyroidism.

Material and methods

This was a case-control study in 58 pregnant patients with SP admitted to the Intensive Care Unit of a High Specialty Unit in Mexico City attended from January 2018 to December 2021. The case group was formed with 29 patients with pre-pregnancy primary hypothyroidism and the control group with 29 age-matched patients with normal pre-pregnancy thyroid function. Their overall data and maternal and fetal outcomes were compared. Descriptive statistics, chi-square test, and Student's t-test with the SPSS version 20 programme were used. A p-value< 0.05 was significant.

Results

No differences were found in age (p = .8292), parity (p = 1), systolic (p = .7229) and diastolic (p = .5498) blood pressure, caesarean section (p = .812), intrapartum haemorrhage (p = .812), p = .3558), anaesthetic technique (p = .5786), obstetric complications, Intensive Care Unit stay (p = .6181), and mortality. There were no differences in the products: singleton pregnancy (p = .912), gestational age (p = .8901), weight (p = .3338), Apgar score minute one and five, prematurity (p = .8701), intensive care (p = .0623), in utero mortality (n = 4 vs n = 4), and mortality at birth (n = 2 vs n = 0).

Conclusions

Maternal and fetal outcomes were similar. The cases with uncontrolled thyroid did not show adverse clinical effects.