Nedasadat Saadati Ardestani , Seyed Ali Sajadian , Adrián Rojas , Ratna Surya Alwi , L. Antonio Estévez
{"title":"法莫替丁在超临界二氧化碳中的溶解度:实验测量和热力学模型","authors":"Nedasadat Saadati Ardestani , Seyed Ali Sajadian , Adrián Rojas , Ratna Surya Alwi , L. Antonio Estévez","doi":"10.1016/j.supflu.2023.106031","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>In the current study, the solubility of famotidine (FAM) in </span>supercritical<span> carbon dioxide (scCO₂) was experimentally determined for the first time. The FAM solubility in scCO₂, expressed as mole fraction, at different temperatures (308 − 338 K) and pressures (12 − 30 MPa) was found to be in the range of 1.40 × 10</span></span><sup>−6</sup> to 1.11 × 10<sup>−4</sup>. Due to the low solubility of FAM in scCO₂, the gas anti-solvent and supercritical anti-solvent processes can be a good option to generate the nano/micro size particles of this drug. The experimental solubility data were correlated by the density-based models of Bartle <em>et al.</em>, Méndez-Santiago and Teja (MST), Jouyban <em>et al.</em> and Hozhabr <em>et al.</em>, by the non-cubic equation of state PC-SAFT, and by the two versions of the Estévez et al. model (ECM-PR and ECM-RK). According to the modeling results, the Estévez et al. model showed the highest accuracy with AARD values of 9.92 (ECM-PR) and 10.70 (ECM-RK). The empirical models also yielded satisfactory outcomes to the correlation of the solubility of FAM in scCO₂.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"201 ","pages":"Article 106031"},"PeriodicalIF":3.4000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Solubility of famotidine in supercritical carbon dioxide: Experimental measurement and thermodynamic modeling\",\"authors\":\"Nedasadat Saadati Ardestani , Seyed Ali Sajadian , Adrián Rojas , Ratna Surya Alwi , L. Antonio Estévez\",\"doi\":\"10.1016/j.supflu.2023.106031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>In the current study, the solubility of famotidine (FAM) in </span>supercritical<span> carbon dioxide (scCO₂) was experimentally determined for the first time. The FAM solubility in scCO₂, expressed as mole fraction, at different temperatures (308 − 338 K) and pressures (12 − 30 MPa) was found to be in the range of 1.40 × 10</span></span><sup>−6</sup> to 1.11 × 10<sup>−4</sup>. Due to the low solubility of FAM in scCO₂, the gas anti-solvent and supercritical anti-solvent processes can be a good option to generate the nano/micro size particles of this drug. The experimental solubility data were correlated by the density-based models of Bartle <em>et al.</em>, Méndez-Santiago and Teja (MST), Jouyban <em>et al.</em> and Hozhabr <em>et al.</em>, by the non-cubic equation of state PC-SAFT, and by the two versions of the Estévez et al. model (ECM-PR and ECM-RK). According to the modeling results, the Estévez et al. model showed the highest accuracy with AARD values of 9.92 (ECM-PR) and 10.70 (ECM-RK). The empirical models also yielded satisfactory outcomes to the correlation of the solubility of FAM in scCO₂.</p></div>\",\"PeriodicalId\":17078,\"journal\":{\"name\":\"Journal of Supercritical Fluids\",\"volume\":\"201 \",\"pages\":\"Article 106031\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Supercritical Fluids\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S089684462300195X\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Supercritical Fluids","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S089684462300195X","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Solubility of famotidine in supercritical carbon dioxide: Experimental measurement and thermodynamic modeling
In the current study, the solubility of famotidine (FAM) in supercritical carbon dioxide (scCO₂) was experimentally determined for the first time. The FAM solubility in scCO₂, expressed as mole fraction, at different temperatures (308 − 338 K) and pressures (12 − 30 MPa) was found to be in the range of 1.40 × 10−6 to 1.11 × 10−4. Due to the low solubility of FAM in scCO₂, the gas anti-solvent and supercritical anti-solvent processes can be a good option to generate the nano/micro size particles of this drug. The experimental solubility data were correlated by the density-based models of Bartle et al., Méndez-Santiago and Teja (MST), Jouyban et al. and Hozhabr et al., by the non-cubic equation of state PC-SAFT, and by the two versions of the Estévez et al. model (ECM-PR and ECM-RK). According to the modeling results, the Estévez et al. model showed the highest accuracy with AARD values of 9.92 (ECM-PR) and 10.70 (ECM-RK). The empirical models also yielded satisfactory outcomes to the correlation of the solubility of FAM in scCO₂.
期刊介绍：
The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics.
Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.
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