Unicentric plasma cell type of Castleman’s disease in the submandibular: A case report and literature review

Castleman’s disease（CD）usually occurs in the mediastinum and rarely occurs in the head and neck region. Almost all CD in the head and neck region is hyaline vascular (HV) type, and plasma cell (PC) type of CD is relatively rare. An 82-year-old woman with a well-defined, elastic, hard, and palpable painless tumor in the left submandibular area was referred to our division. Magnetic resonance imaging of the tumor revealed low signal intensity on T1-weighted images, moderate to high signal intensity on T2-weighed images. Fine needle aspiration was performed, and no dysplasia was detected. Tumorectomy was performed under general anesthesia. The histopathological diagnosis was PC type of CD. There was no recurrence at follow-up 10 months after surgery. Herein, we present the first female and the oldest case of PC type of CD in the submandibular.