{"title":"ω-3多不饱和脂肪酸对帕金森病患者促炎和抗炎细胞因子水平及脂质状况的影响","authors":"Sara Mohammadi , Mirmohsen Sharifi Bonab , Mahdyieh Hamed Behzad , Bahram Pourghassem Gargari","doi":"10.1016/j.nupar.2023.06.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Parkinson's disease (PD) is associated with inflammation and lipid profile abnormalities. Considering the effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on inflammation and lipid metabolism, the present study aimed to investigate the effects of ω-3 PUFAs supplementation on the pro- and anti-inflammatory cytokines and lipid profile in PD.</p></div><div><h3>Material and methods</h3><p>In this study, 44 patients with PD were selected and divided into two groups. The intervention group received two capsules of ω-3 PUFAs daily, each capsule containing 120<!--> <!-->mg eicosapentaenoic acid and 180<!--> <span>mg docosahexaenoic acid, and the placebo group received two soft capsules of soybean oil daily for eight weeks. Weight, height, lipid profile (TG, HDL-c, LDL-c, total cholesterol [TC]), and pro- and anti-inflammatory cytokines (IL-6, TNF-α, and IL-10) were assessed at the beginning and at the end of the study.</span></p></div><div><h3>Results</h3><p>Body mass index (<em>P</em> <!-->=<!--> <!-->0.02), weight (<em>P</em> <!-->=<!--> <!-->0.04), HDL-c (<em>P</em> <!-->=<!--> <!-->0.01), LDL-c (<em>P</em> <!-->=<!--> <!-->0.03), and IL-6 (<em>P</em> <!-->=<!--> <span>0.02) levels increased, while TG (</span><em>P</em> <!-->=<!--> <!-->0.01), TNF-α (<em>P</em> <!-->=<!--> <!-->0.01), and IL-10 (<em>P</em> <!-->=<!--> <!-->0.01) decreased significantly in the ω-3 PUFAs group. Between-group comparisons revealed the changes not to be significant after adjustments for baseline values and confounders. Moreover, the changes in TC were not significant in either within- or between-group comparisons.</p></div><div><h3>Conclusion</h3><p>Based on the results of the study, 600<!--> <!-->mg ω-3 PUFAs supplementation for eight weeks has no significant effect on the assessed pro- and anti-inflammatory cytokines and lipid profiles in patients with PD. Further studies with higher doses are needed to better clarify the role of ω-3 PUFAs in the biochemical and clinical outcomes of PD patients.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Pages 181-187"},"PeriodicalIF":0.5000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of omega-3 polyunsaturated fatty acids on the levels of pro- and anti-inflammatory cytokines and lipid profile in patients with Parkinson's disease\",\"authors\":\"Sara Mohammadi , Mirmohsen Sharifi Bonab , Mahdyieh Hamed Behzad , Bahram Pourghassem Gargari\",\"doi\":\"10.1016/j.nupar.2023.06.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Parkinson's disease (PD) is associated with inflammation and lipid profile abnormalities. Considering the effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on inflammation and lipid metabolism, the present study aimed to investigate the effects of ω-3 PUFAs supplementation on the pro- and anti-inflammatory cytokines and lipid profile in PD.</p></div><div><h3>Material and methods</h3><p>In this study, 44 patients with PD were selected and divided into two groups. The intervention group received two capsules of ω-3 PUFAs daily, each capsule containing 120<!--> <!-->mg eicosapentaenoic acid and 180<!--> <span>mg docosahexaenoic acid, and the placebo group received two soft capsules of soybean oil daily for eight weeks. Weight, height, lipid profile (TG, HDL-c, LDL-c, total cholesterol [TC]), and pro- and anti-inflammatory cytokines (IL-6, TNF-α, and IL-10) were assessed at the beginning and at the end of the study.</span></p></div><div><h3>Results</h3><p>Body mass index (<em>P</em> <!-->=<!--> <!-->0.02), weight (<em>P</em> <!-->=<!--> <!-->0.04), HDL-c (<em>P</em> <!-->=<!--> <!-->0.01), LDL-c (<em>P</em> <!-->=<!--> <!-->0.03), and IL-6 (<em>P</em> <!-->=<!--> <span>0.02) levels increased, while TG (</span><em>P</em> <!-->=<!--> <!-->0.01), TNF-α (<em>P</em> <!-->=<!--> <!-->0.01), and IL-10 (<em>P</em> <!-->=<!--> <!-->0.01) decreased significantly in the ω-3 PUFAs group. Between-group comparisons revealed the changes not to be significant after adjustments for baseline values and confounders. Moreover, the changes in TC were not significant in either within- or between-group comparisons.</p></div><div><h3>Conclusion</h3><p>Based on the results of the study, 600<!--> <!-->mg ω-3 PUFAs supplementation for eight weeks has no significant effect on the assessed pro- and anti-inflammatory cytokines and lipid profiles in patients with PD. Further studies with higher doses are needed to better clarify the role of ω-3 PUFAs in the biochemical and clinical outcomes of PD patients.</p></div>\",\"PeriodicalId\":54702,\"journal\":{\"name\":\"Nutrition Clinique et Metabolisme\",\"volume\":\"37 3\",\"pages\":\"Pages 181-187\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Clinique et Metabolisme\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0985056223002455\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Clinique et Metabolisme","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0985056223002455","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Effects of omega-3 polyunsaturated fatty acids on the levels of pro- and anti-inflammatory cytokines and lipid profile in patients with Parkinson's disease
Objective
Parkinson's disease (PD) is associated with inflammation and lipid profile abnormalities. Considering the effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on inflammation and lipid metabolism, the present study aimed to investigate the effects of ω-3 PUFAs supplementation on the pro- and anti-inflammatory cytokines and lipid profile in PD.
Material and methods
In this study, 44 patients with PD were selected and divided into two groups. The intervention group received two capsules of ω-3 PUFAs daily, each capsule containing 120 mg eicosapentaenoic acid and 180 mg docosahexaenoic acid, and the placebo group received two soft capsules of soybean oil daily for eight weeks. Weight, height, lipid profile (TG, HDL-c, LDL-c, total cholesterol [TC]), and pro- and anti-inflammatory cytokines (IL-6, TNF-α, and IL-10) were assessed at the beginning and at the end of the study.
Results
Body mass index (P = 0.02), weight (P = 0.04), HDL-c (P = 0.01), LDL-c (P = 0.03), and IL-6 (P = 0.02) levels increased, while TG (P = 0.01), TNF-α (P = 0.01), and IL-10 (P = 0.01) decreased significantly in the ω-3 PUFAs group. Between-group comparisons revealed the changes not to be significant after adjustments for baseline values and confounders. Moreover, the changes in TC were not significant in either within- or between-group comparisons.
Conclusion
Based on the results of the study, 600 mg ω-3 PUFAs supplementation for eight weeks has no significant effect on the assessed pro- and anti-inflammatory cytokines and lipid profiles in patients with PD. Further studies with higher doses are needed to better clarify the role of ω-3 PUFAs in the biochemical and clinical outcomes of PD patients.
期刊介绍：
Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.
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