新冠肺炎突破性感染与睡眠障碍:基于人群的倾向匹配分析

Q1 Medicine
Mantavya Punj , Aakash Desai , Jana G. Hashash , Francis A. Farraye , Pablo R. Castillo
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引用次数: 0

摘要

目的研究接种疫苗的选定睡眠障碍患者发生突破性新冠肺炎感染的风险。方法使用TriNetX平台实时搜索和分析,评估ICD-10诊断为失眠、昼夜节律紊乱和睡眠不足的患者患新冠肺炎突破性感染(BTI)的风险。睡眠障碍和对照组进行了倾向匹配,包括年龄、性别、种族、民族和多种合并疾病的因素。结果24720名患者中,815名(3.2%)出现了BTI,这些患者被确定患有与失眠、昼夜节律紊乱或睡眠不足有关的睡眠障碍。在睡眠障碍和对照组之间发现BTI的风险显著增加(调整比值比(aOR)为1.40,95%置信区间(CI)为1.23-1.58)。亚组分析显示,接受两剂(aOR 1.53,95%CI 1.24-1.89)BTI的风险高于接受三剂(aOR1.45,95%CI 1.23-1.69)BTI。没有发现睡眠障碍患者住院、插管、死亡或死亡和插管复合结果的风险增加。结论诊断为失眠、昼夜节律紊乱或睡眠不足与新冠肺炎突破性感染风险增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID-19 breakthrough infections and sleep disorders: A population-based propensity matched analysis

Objectives

Examine risks for breakthrough COVID-19 infections in vaccinated patients with selected sleep disorders.

Methods

Real-time search and analysis using the TriNetX platform to evaluate risk of COVID-19 breakthrough infections (BTI) for patients having ICD-10 diagnoses relating to insomnia, circadian rhythm disorders, and inadequate sleep. The sleep disorder and control cohorts underwent propensity matching including factors for age, gender, race, ethnicity, and multiple co-morbid conditions.

Results

Of 24,720 patients identified as having a sleep disturbance relating to insomnia, circadian rhythm disorder, or inadequate sleep, 815 (3.2 %) were found to have a developed a BTI. There was a significant increased risk of BTI noted between the sleep disorder and control cohorts (adjusted odds ratio (aOR) of 1.40, 95 % confidence interval (CI) of 1.23–1.58). Subgroup analysis showed an elevated risk for BTI receiving two doses (aOR 1.53, 95 % CI 1.24–1.89) versus three doses (aOR 1.45, 95 % CI 1.24–1.69). Patients with the sleep disturbance were not found to be at an increased risk of hospitalization, intubation, death, or composite outcome of death and intubation.

Conclusion

The presence of having a diagnosis of insomnia, circadian rhythm disorder, or inadequate sleep was associated with increased risk of COVID-19 breakthrough infection.

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来源期刊
Sleep Medicine: X
Sleep Medicine: X Medicine-Medicine (all)
CiteScore
4.00
自引率
0.00%
发文量
17
审稿时长
25 weeks
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