Tom Sherman FRCOphth , Ian A.S. Rodrigues FRCOphth , Saurabh Goyal FRCS, FRCOphth , Pouya Alaghband MD, FRCOphth , Philip Bloom FRCS, FRCOphth , Keith Barton MD, FRCS , Hari Jayaram PhD, FRCOphth , Mohammed Abu-Bakra FRCOphth , Melody Ni PhD , Kin Sheng Lim MD, FRCOphth
{"title":"超声乳化+内镜激光循环光凝与单纯超声乳化治疗白内障原发性开角型青光眼的疗效比较","authors":"Tom Sherman FRCOphth , Ian A.S. Rodrigues FRCOphth , Saurabh Goyal FRCS, FRCOphth , Pouya Alaghband MD, FRCOphth , Philip Bloom FRCS, FRCOphth , Keith Barton MD, FRCS , Hari Jayaram PhD, FRCOphth , Mohammed Abu-Bakra FRCOphth , Melody Ni PhD , Kin Sheng Lim MD, FRCOphth","doi":"10.1016/j.ogla.2023.03.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To describe the methodology of the Comparing the Effectiveness of Phacoemulsification + Endoscopic Cyclophotocoagulation Laser and Phacoemulsification Alone for the Treatment of Primary Open Angle Glaucoma in Patients with Cataract (CONCEPT) study, a randomized controlled trial.</p></div><div><h3>Design</h3><p>Double-masked, randomized controlled trial.</p></div><div><h3>Subjects, Participants, and/or Controls</h3><p>Participants will be recruited from 5 United Kingdom–based centers. One hundred and sixty eyes with a diagnosis of primary open-angle glaucoma and visually significant cataract will be included. Eighty eyes will be randomized to undergo cataract surgery alone and eighty to undergo cataract surgery with endoscopic cyclophotocoagulation (ECP).</p></div><div><h3>Methods</h3><p>The baseline diurnal washout intraocular pressure (IOP) will be measured. The participants will be randomized to undergo cataract surgery alone or cataract surgery with ECP upon completion of uncomplicated cataract surgery. At the 1- and 2-year post surgery follow-up visits, the measurements of washout diurnal IOP will be repeated.</p></div><div><h3>Main Outcome Measures</h3><p>Diurnal washout IOP, use of glaucoma medications, and adverse events.</p></div><div><h3>Conclusions</h3><p>We described the methodology of the first randomized controlled trial comparing cataract surgery alone with cataract surgery combined with ECP in the context of patients with primary open-angle glaucoma and symptomatic cataract.</p></div><div><h3>Financial Disclosure(s)</h3><p>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparing the Effectiveness of Phacoemulsification + Endoscopic Cyclophotocoagulation Laser versus Phacoemulsification Alone for the Treatment of Primary Open Angle Glaucoma in Patients with Cataract (CONCEPT)\",\"authors\":\"Tom Sherman FRCOphth , Ian A.S. Rodrigues FRCOphth , Saurabh Goyal FRCS, FRCOphth , Pouya Alaghband MD, FRCOphth , Philip Bloom FRCS, FRCOphth , Keith Barton MD, FRCS , Hari Jayaram PhD, FRCOphth , Mohammed Abu-Bakra FRCOphth , Melody Ni PhD , Kin Sheng Lim MD, FRCOphth\",\"doi\":\"10.1016/j.ogla.2023.03.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To describe the methodology of the Comparing the Effectiveness of Phacoemulsification + Endoscopic Cyclophotocoagulation Laser and Phacoemulsification Alone for the Treatment of Primary Open Angle Glaucoma in Patients with Cataract (CONCEPT) study, a randomized controlled trial.</p></div><div><h3>Design</h3><p>Double-masked, randomized controlled trial.</p></div><div><h3>Subjects, Participants, and/or Controls</h3><p>Participants will be recruited from 5 United Kingdom–based centers. One hundred and sixty eyes with a diagnosis of primary open-angle glaucoma and visually significant cataract will be included. Eighty eyes will be randomized to undergo cataract surgery alone and eighty to undergo cataract surgery with endoscopic cyclophotocoagulation (ECP).</p></div><div><h3>Methods</h3><p>The baseline diurnal washout intraocular pressure (IOP) will be measured. The participants will be randomized to undergo cataract surgery alone or cataract surgery with ECP upon completion of uncomplicated cataract surgery. At the 1- and 2-year post surgery follow-up visits, the measurements of washout diurnal IOP will be repeated.</p></div><div><h3>Main Outcome Measures</h3><p>Diurnal washout IOP, use of glaucoma medications, and adverse events.</p></div><div><h3>Conclusions</h3><p>We described the methodology of the first randomized controlled trial comparing cataract surgery alone with cataract surgery combined with ECP in the context of patients with primary open-angle glaucoma and symptomatic cataract.</p></div><div><h3>Financial Disclosure(s)</h3><p>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p></div>\",\"PeriodicalId\":19519,\"journal\":{\"name\":\"Ophthalmology. 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Comparing the Effectiveness of Phacoemulsification + Endoscopic Cyclophotocoagulation Laser versus Phacoemulsification Alone for the Treatment of Primary Open Angle Glaucoma in Patients with Cataract (CONCEPT)
Objective
To describe the methodology of the Comparing the Effectiveness of Phacoemulsification + Endoscopic Cyclophotocoagulation Laser and Phacoemulsification Alone for the Treatment of Primary Open Angle Glaucoma in Patients with Cataract (CONCEPT) study, a randomized controlled trial.
Design
Double-masked, randomized controlled trial.
Subjects, Participants, and/or Controls
Participants will be recruited from 5 United Kingdom–based centers. One hundred and sixty eyes with a diagnosis of primary open-angle glaucoma and visually significant cataract will be included. Eighty eyes will be randomized to undergo cataract surgery alone and eighty to undergo cataract surgery with endoscopic cyclophotocoagulation (ECP).
Methods
The baseline diurnal washout intraocular pressure (IOP) will be measured. The participants will be randomized to undergo cataract surgery alone or cataract surgery with ECP upon completion of uncomplicated cataract surgery. At the 1- and 2-year post surgery follow-up visits, the measurements of washout diurnal IOP will be repeated.
Main Outcome Measures
Diurnal washout IOP, use of glaucoma medications, and adverse events.
Conclusions
We described the methodology of the first randomized controlled trial comparing cataract surgery alone with cataract surgery combined with ECP in the context of patients with primary open-angle glaucoma and symptomatic cataract.
Financial Disclosure(s)
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.