Jie Zhang , Xiaorui Ma , Wei Wang , Caixia Wu , Ben Ma , Chong Yu , Haifeng Wang
{"title":"姜黄根中的三种新倍半萜","authors":"Jie Zhang , Xiaorui Ma , Wei Wang , Caixia Wu , Ben Ma , Chong Yu , Haifeng Wang","doi":"10.1016/j.chmed.2022.11.007","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To study the chemical constituents from the roots of <em>Curcuma longa</em>.</p></div><div><h3>Methods</h3><p>The structures of the compounds were elucidated based on extensive spectral analysis, including 1D and 2D NMR, MS, UV, and CD analysis.</p></div><div><h3>Results</h3><p>Two new sesquiterpene compounds (1<em>S</em>,2<em>R</em>,5<em>R</em>,7<em>S</em>,8<em>R</em>)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (<strong>1</strong>), (1<em>R</em>,2<em>R</em>,5<em>R</em>,7<em>S</em>,8<em>R</em>)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (<strong>2</strong>), and a new natural product 6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one (<strong>3</strong>) together with three known compounds <em>ar</em>-turmerone (<strong>4</strong>), 2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (<strong>5</strong>) and 2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (<strong>6</strong>) were isolated from <em>C. longa</em> root extract with 95% ethanol.</p></div><div><h3>Conclusion</h3><p>In the study, three new compounds were isolated from <em>C. longa</em>, and their absolute configurations were determined.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Three new sesquiterpenes from roots of Curcuma longa\",\"authors\":\"Jie Zhang , Xiaorui Ma , Wei Wang , Caixia Wu , Ben Ma , Chong Yu , Haifeng Wang\",\"doi\":\"10.1016/j.chmed.2022.11.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To study the chemical constituents from the roots of <em>Curcuma longa</em>.</p></div><div><h3>Methods</h3><p>The structures of the compounds were elucidated based on extensive spectral analysis, including 1D and 2D NMR, MS, UV, and CD analysis.</p></div><div><h3>Results</h3><p>Two new sesquiterpene compounds (1<em>S</em>,2<em>R</em>,5<em>R</em>,7<em>S</em>,8<em>R</em>)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (<strong>1</strong>), (1<em>R</em>,2<em>R</em>,5<em>R</em>,7<em>S</em>,8<em>R</em>)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (<strong>2</strong>), and a new natural product 6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one (<strong>3</strong>) together with three known compounds <em>ar</em>-turmerone (<strong>4</strong>), 2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (<strong>5</strong>) and 2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (<strong>6</strong>) were isolated from <em>C. longa</em> root extract with 95% ethanol.</p></div><div><h3>Conclusion</h3><p>In the study, three new compounds were isolated from <em>C. longa</em>, and their absolute configurations were determined.</p></div>\",\"PeriodicalId\":9916,\"journal\":{\"name\":\"Chinese Herbal Medicines\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Herbal Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1674638423000503\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Herbal Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1674638423000503","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Three new sesquiterpenes from roots of Curcuma longa
Objective
To study the chemical constituents from the roots of Curcuma longa.
Methods
The structures of the compounds were elucidated based on extensive spectral analysis, including 1D and 2D NMR, MS, UV, and CD analysis.
Results
Two new sesquiterpene compounds (1S,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (1), (1R,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (2), and a new natural product 6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one (3) together with three known compounds ar-turmerone (4), 2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (5) and 2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (6) were isolated from C. longa root extract with 95% ethanol.
Conclusion
In the study, three new compounds were isolated from C. longa, and their absolute configurations were determined.
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