A. Gómez-Grande , A.P. Seiffert , A. Villarejo-Galende , M. González-Sánchez , S. Llamas-Velasco , H. Bueno , E.J. Gómez , M.J. Tabuenca , P. Sánchez-González
{"title":"原发性进行性失语症患者第一分钟静态淀粉样蛋白PET图像与[18F]FDG PET相关","authors":"A. Gómez-Grande , A.P. Seiffert , A. Villarejo-Galende , M. González-Sánchez , S. Llamas-Velasco , H. Bueno , E.J. Gómez , M.J. Tabuenca , P. Sánchez-González","doi":"10.1016/j.remn.2022.10.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with <sup>18</sup>F-labeled amyloid-binding radiotracers and brain [<sup>18</sup>F]FDG PET in patients with primary progressive aphasia (PPA).</p></div><div><h3>Material and methods</h3><p>The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9<!--> <!-->nonfluent variant PPA, 4<!--> <!-->logopenic variant PPA, 1<!--> <!-->semantic variant PPA, 3<!--> <!-->unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [<sup>18</sup>F]FDG PET images and Pearson's correlation coefficients are calculated.</p></div><div><h3>Results</h3><p>SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of <em>r</em> <!-->=<!--> <!-->.94 ±<!--> <!-->.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.</p></div><div><h3>Conclusions</h3><p>The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 4","pages":"Pages 211-217"},"PeriodicalIF":1.6000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Una imagen PET amiloide estática del primer minuto (FMF) se correlaciona con [18F]FDG PET en pacientes con afasia progresiva primaria\",\"authors\":\"A. Gómez-Grande , A.P. Seiffert , A. Villarejo-Galende , M. González-Sánchez , S. Llamas-Velasco , H. Bueno , E.J. Gómez , M.J. Tabuenca , P. Sánchez-González\",\"doi\":\"10.1016/j.remn.2022.10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with <sup>18</sup>F-labeled amyloid-binding radiotracers and brain [<sup>18</sup>F]FDG PET in patients with primary progressive aphasia (PPA).</p></div><div><h3>Material and methods</h3><p>The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9<!--> <!-->nonfluent variant PPA, 4<!--> <!-->logopenic variant PPA, 1<!--> <!-->semantic variant PPA, 3<!--> <!-->unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [<sup>18</sup>F]FDG PET images and Pearson's correlation coefficients are calculated.</p></div><div><h3>Results</h3><p>SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of <em>r</em> <!-->=<!--> <!-->.94 ±<!--> <!-->.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.</p></div><div><h3>Conclusions</h3><p>The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.</p></div>\",\"PeriodicalId\":48986,\"journal\":{\"name\":\"Revista Espanola De Medicina Nuclear E Imagen Molecular\",\"volume\":\"42 4\",\"pages\":\"Pages 211-217\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Espanola De Medicina Nuclear E Imagen Molecular\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2253654X22001391\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Espanola De Medicina Nuclear E Imagen Molecular","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2253654X22001391","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Una imagen PET amiloide estática del primer minuto (FMF) se correlaciona con [18F]FDG PET en pacientes con afasia progresiva primaria
Objective
To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with 18F-labeled amyloid-binding radiotracers and brain [18F]FDG PET in patients with primary progressive aphasia (PPA).
Material and methods
The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [18F]FDG PET images and Pearson's correlation coefficients are calculated.
Results
SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of r = .94 ± .06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.
Conclusions
The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.
期刊介绍：
The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members.
The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles.
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