膜受力:G蛋白偶联受体的机械感觉及其解决方法

IF 2.5 Q2 PHYSIOLOGY
Katie Hardman , Adrian Goldman , Christos Pliotas
{"title":"膜受力:G蛋白偶联受体的机械感觉及其解决方法","authors":"Katie Hardman ,&nbsp;Adrian Goldman ,&nbsp;Christos Pliotas","doi":"10.1016/j.cophys.2023.100689","DOIUrl":null,"url":null,"abstract":"<div><p>To survive, all organisms must detect and respond to mechanical cues in their environment. Cells are subjected to a plethora of mechanical forces, such as hydrostatic pressure, cell-cell contact, stretch, compression, and shear stress. Mechanosensitive (MS) membrane proteins have evolved across all life kingdoms to sense and respond to forces in the membrane. Bacterial MS ion channels provide a blueprint for understanding the fundamental mechanisms that underpin cellular responses to mechanical signals. Recently, the identification of eukaryotic force transducers, which includes membrane proteins other than channels, has led to the recognition of common structural hallmarks and unified biophysical mechanisms that could potentially link these diverse proteins. Accumulating evidence suggests G protein-coupled receptors (GPCRs) are candidates for pressure sensing in mammals. This review summarises the current knowledge on MS GPCRs, describes the tools used to assess their mechanosensitivity, and aims to highlight the key characteristics that link these receptors to established mechanosensors.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Membrane force reception: mechanosensation in G protein-coupled receptors and tools to address it\",\"authors\":\"Katie Hardman ,&nbsp;Adrian Goldman ,&nbsp;Christos Pliotas\",\"doi\":\"10.1016/j.cophys.2023.100689\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>To survive, all organisms must detect and respond to mechanical cues in their environment. Cells are subjected to a plethora of mechanical forces, such as hydrostatic pressure, cell-cell contact, stretch, compression, and shear stress. Mechanosensitive (MS) membrane proteins have evolved across all life kingdoms to sense and respond to forces in the membrane. Bacterial MS ion channels provide a blueprint for understanding the fundamental mechanisms that underpin cellular responses to mechanical signals. Recently, the identification of eukaryotic force transducers, which includes membrane proteins other than channels, has led to the recognition of common structural hallmarks and unified biophysical mechanisms that could potentially link these diverse proteins. Accumulating evidence suggests G protein-coupled receptors (GPCRs) are candidates for pressure sensing in mammals. This review summarises the current knowledge on MS GPCRs, describes the tools used to assess their mechanosensitivity, and aims to highlight the key characteristics that link these receptors to established mechanosensors.</p></div>\",\"PeriodicalId\":52156,\"journal\":{\"name\":\"Current Opinion in Physiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468867323000597\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468867323000597","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

为了生存,所有生物都必须检测到环境中的机械信号并对其做出反应。细胞受到过多的机械力,如静水压力、细胞-细胞接触、拉伸、压缩和剪切应力。机械敏感(MS)膜蛋白已经在所有生命王国中进化,以感知和响应膜中的力。细菌MS离子通道为理解细胞对机械信号反应的基本机制提供了蓝图。最近,真核生物力传感器的鉴定,包括通道以外的膜蛋白,已经导致了对共同结构特征的识别和可能将这些不同蛋白质联系起来的统一生物物理机制。越来越多的证据表明,G蛋白偶联受体(GPCR)是哺乳动物压力传感的候选者。这篇综述总结了MS GPCR的当前知识,描述了用于评估其机械敏感性的工具,并旨在强调将这些受体与已建立的机械传感器联系起来的关键特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Membrane force reception: mechanosensation in G protein-coupled receptors and tools to address it

To survive, all organisms must detect and respond to mechanical cues in their environment. Cells are subjected to a plethora of mechanical forces, such as hydrostatic pressure, cell-cell contact, stretch, compression, and shear stress. Mechanosensitive (MS) membrane proteins have evolved across all life kingdoms to sense and respond to forces in the membrane. Bacterial MS ion channels provide a blueprint for understanding the fundamental mechanisms that underpin cellular responses to mechanical signals. Recently, the identification of eukaryotic force transducers, which includes membrane proteins other than channels, has led to the recognition of common structural hallmarks and unified biophysical mechanisms that could potentially link these diverse proteins. Accumulating evidence suggests G protein-coupled receptors (GPCRs) are candidates for pressure sensing in mammals. This review summarises the current knowledge on MS GPCRs, describes the tools used to assess their mechanosensitivity, and aims to highlight the key characteristics that link these receptors to established mechanosensors.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Current Opinion in Physiology
Current Opinion in Physiology Medicine-Physiology (medical)
CiteScore
5.80
自引率
0.00%
发文量
52
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信