Marijana Ranisavljev , Nikola Todorovic , Jovana Panic , Bogdan Andjelic , Milan Vranes , Sergej M. Ostojic
{"title":"短期禁食影响健康男性和女性肌酸代谢的生物标志物","authors":"Marijana Ranisavljev , Nikola Todorovic , Jovana Panic , Bogdan Andjelic , Milan Vranes , Sergej M. Ostojic","doi":"10.1016/j.hnm.2023.200217","DOIUrl":null,"url":null,"abstract":"<div><p>We studied the effects of 24-h fasting on serum levels of guanidinoacetic acid (GAA), creatine, and creatinine in 24 non-vegetarian healthy adults. Blood was taken before and following an intervention, with levels corrected for fasting-induced changes in plasma volume. Food abstention induced a significant decrease in serum GAA by 39.5% (<em>p</em> < 0.001), while creatinine levels increased by 14.7% (<em>p</em> < 0.01); the concentration of creatine remains unchanged. The reduction in GAA during fasting may indicate an increased demand for creatine production for this energy-demanding condition and/or potential kidney dysfunction which requires further exploration.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Short-term fasting affects biomarkers of creatine metabolism in healthy men and women\",\"authors\":\"Marijana Ranisavljev , Nikola Todorovic , Jovana Panic , Bogdan Andjelic , Milan Vranes , Sergej M. Ostojic\",\"doi\":\"10.1016/j.hnm.2023.200217\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We studied the effects of 24-h fasting on serum levels of guanidinoacetic acid (GAA), creatine, and creatinine in 24 non-vegetarian healthy adults. Blood was taken before and following an intervention, with levels corrected for fasting-induced changes in plasma volume. Food abstention induced a significant decrease in serum GAA by 39.5% (<em>p</em> < 0.001), while creatinine levels increased by 14.7% (<em>p</em> < 0.01); the concentration of creatine remains unchanged. The reduction in GAA during fasting may indicate an increased demand for creatine production for this energy-demanding condition and/or potential kidney dysfunction which requires further exploration.</p></div>\",\"PeriodicalId\":36125,\"journal\":{\"name\":\"Human Nutrition and Metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2023-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human Nutrition and Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666149723000348\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Nutrition and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666149723000348","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Short-term fasting affects biomarkers of creatine metabolism in healthy men and women
We studied the effects of 24-h fasting on serum levels of guanidinoacetic acid (GAA), creatine, and creatinine in 24 non-vegetarian healthy adults. Blood was taken before and following an intervention, with levels corrected for fasting-induced changes in plasma volume. Food abstention induced a significant decrease in serum GAA by 39.5% (p < 0.001), while creatinine levels increased by 14.7% (p < 0.01); the concentration of creatine remains unchanged. The reduction in GAA during fasting may indicate an increased demand for creatine production for this energy-demanding condition and/or potential kidney dysfunction which requires further exploration.