对头颈部癌患者进行长期肺癌筛查是否合理?

IF 0.9 Q3 OTORHINOLARYNGOLOGY
Xavier León , Ana Gimenez , Julia de Juan , Camilo Rodríguez , Miquel Quer , Albert Pujol
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引用次数: 0

摘要

目的头颈部鳞状细胞癌(HNSCC)患者发生第二肺肿瘤的风险高于普通人群。本研究的目的是评估诊断为HNSCC后第二肺恶性肿瘤的长期发病率,并考虑在这些患者中筛查肺癌癌症的便利性。材料和方法我们在1985年至2017年期间对4954名口腔、口咽、下咽或喉部指数性肿瘤患者进行了回顾性研究。结果在随访期间,469名患者(9.5%)出现了第二个肺部肿瘤。第二肺肿瘤的发生率为每年1.26%,在分析的25年随访期间几乎保持不变。根据一项多变量研究的结果,年龄在50至80岁之间、有吸烟史、肿瘤位于口咽或声门上的男性患者是第二肺肿瘤风险最高的患者。结论HNSCC指数肿瘤患者发生肺部第二次肿瘤的风险较高。为了实现对这些第二种肿瘤的早期诊断,建议在使用低剂量肺部CT的基础上制定筛查方案,在随访期间应无限期保持低剂量肺部CT。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
¿Está justificado hacer un screening a largo plazo para el cáncer de pulmón en los pacientes con un carcinoma de cabeza y cuello?

Objective

Patients with head and neck squamous cell carcinoma (HNSCC) have a higher risk of second lung neoplasms than the general population. The aim of the present study is to evaluate the long-term incidence of second lung malignancies after the diagnosis of a HNSCC and to consider the convenience of the screening for lung cancer in these patients.

Material and methods

We conducted a retrospective study performed on 4,954 patients with an index tumor located in the oral cavity, oropharynx, hypopharynx, or larynx during the period 1985-2017.

Results

During the follow-up period 469 patients (9.5%) presented a second pulmonary neoplasm. The incidence of second lung neoplasm was 1.26% per year and remained practically constant throughout the 25-year follow-up period analyzed. According to the results of a multivariate study, male patients, aged between 50 and 80 years, with a history of tobacco use, and with tumors located in the oropharynx or the supraglottis were those with the highest risk of second lung neoplasms.

Conclusion

Patients with a HNSCC index tumor have a high risk of second neoplasms located in the lung. In order to achieve an early diagnosis of these second neoplasms, it would be advisable to establish screening protocols based on the use of low-dose lung CT, which should be maintained indefinitely during the follow-up period.

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来源期刊
CiteScore
1.40
自引率
20.00%
发文量
44
审稿时长
44 days
期刊介绍: Es la revista más importante en español dedicada a la especialidad. Ofrece progresos científicos y técnicos tanto a nivel de originales como de casos clínicos. Además, es la Publicación Oficial de la Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial y está presente en los más prestigiosos índices de referencia.
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