农村低收入门诊患者无症状疟疾与血糖的关系

IF 1 Q4 ENDOCRINOLOGY & METABOLISM

Diabetes epidemiology and management Pub Date : 2023-01-01 DOI:10.1016/j.deman.2022.100112

Francis Xavier Kasujja , Fred Nuwaha , Elizabeth Kiracho Ekirapa , Ronald Kusolo , Roy William Mayega

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引用次数: 1

摘要

背景疟疾和溶血与大多数血糖指数改变有关。本研究旨在评估无症状疟疾与空腹血糖（FPG）、糖化血红蛋白（HBA1c）和口服葡萄糖耐量（OGT）测试之间的关系。方法在乌干达东部某综合医院进行横断面调查。符合条件的参与者是30-75岁的患者，他们在门诊部寻求治疗，糖尿病状况不明。参与者接受了FPG、OGT和HBA1c测试。对三个试验进行多元线性回归和ROC曲线分析。结果共有504名参与者参加了该研究，其中78.4%（395）为女性。在调整了年龄、性别和BMI后，无症状疟疾患者的平均HBA1c[-5 mmol/mol（95%CI，-7-2）和OGT测试水平[-1.75 mmol/l（-2.6，-0.8）]较低。无症状疟疾人群的糖尿病最佳临界点HBA1c测试较低[6.5%（47 mmol/mol）对6.6%（49 mmol/mol结论这些发现可能对疟疾流行环境中的糖尿病筛查有意义。

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The association between asymptomatic malaria and blood glucose among outpatients in a rural low-income setting

Background

Malaria and haemolysis have been linked to a preponderance of altered glycaemic indices. This study set out to estimate the association between asymptomatic malaria and the Fasting Plasma Glucose (FPG), glycated haemoglobin (HBA1c) and Oral Glucose Tolerance (OGT) tests.

Methods

A cross-sectional survey was conducted at a general hospital in eastern Uganda. Eligible participants were patients aged 30–75 years, seeking care at the outpatient department, of unknown diabetes status. Participants were tested for FPG, OGT and HBA1c tests. Multiple linear regression and ROC curve analysis were conducted for the three tests.

Results

A total of 504 participants were enrolled on the study, of whom 78.4% (395) were female. After adjusting for age, sex, and BMI, individuals with asymptomatic malaria had lower average HBA1c [-5 mmol/mol (95% CI, -7 -2) and OGT tests levels [-1.75 mmol/l (-2.6, -0.8)]. The optimal cut-off points for diabetes among individuals with asymptomatic malaria were lower for the HBA1c test [6.5% (47 mmol/mol) versus 6.6% (49 mmol/mol), respectively] but higher for the FPG test (6.6 mmol/l versus 6.2 mmol/l, respectively).