{"title":"Nardostachys jatamansi (D.Don) DC治疗脑卒中后抑郁的疗效:一项随机、双盲、对照试验","authors":"Muzafar Din Ahmad Bhat, Husain Ahmad","doi":"10.1016/j.bbii.2023.100012","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Post-stroke Depression (PSD) is a frequent neuropsychiatric manifestation of high clinical importance as it adversely affects recovery and quality of life, interferes with rehabilitation, and is a significant source of burden to caregivers. Prevalence rates of PSD range from 25% to 79%. The reason for treatment failure in patients of PSD includes the timing of intervention or the side effects of medications. <em>Nardostachys jatamansi</em> (D.Don) DC is commonly used in traditional medicine systems for neuropsychiatric and psychosomatic disorders with the least or no side effects. However, its clinical efficacy in PSD remains unraveled. The study aimed to evaluate the efficacy of <em>Nardostachys jatamansi</em> in PSD.</p></div><div><h3>Methods</h3><p>Present study was a double-blind randomized placebo-controlled trial with 20 patients in each test and control group. Participants were randomly allocated to receive <em>Nardostachys jatamansi</em> 3gms (powder) in the test group or placebo in the control group for six weeks. Participants were asked to follow up fortnightly for the assessment of subjective parameters. Objective parameters (Hamilton Depression Rating Scale (HDRS<sub>17</sub>) score and 36-Item Short Form Survey <strong>(</strong>SF-36) were assessed at baseline and end of the trial.</p></div><div><h3>Results</h3><p>After 6 weeks of treatment, there was a statistically significant reduction in HDRS<sub>17</sub> score and SF-36 (p < 0.001), whereas there was no significant difference in the control group (P = 0.108, and 0.29 respectively). Comparison between baseline and post-treatment scores in the test group showed a positive reduction in all subjective parameters however, in the control group there was no statistically significant change. The intergroup analysis revealed that the reduction in HDRS<sub>17</sub> score and improvement in SF-36 score was statistically significant in the test group than the control group (P < 0.001).</p></div><div><h3>Conclusion</h3><p>The study revealed that the test drug is effective in the management of PSD. There was no adverse effect observed during the trial.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"2 ","pages":"Article 100012"},"PeriodicalIF":0.0000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Efficacy of Nardostachys jatamansi (D.Don) DC in post stroke depression: A randomized, double blind, controlled trial\",\"authors\":\"Muzafar Din Ahmad Bhat, Husain Ahmad\",\"doi\":\"10.1016/j.bbii.2023.100012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Post-stroke Depression (PSD) is a frequent neuropsychiatric manifestation of high clinical importance as it adversely affects recovery and quality of life, interferes with rehabilitation, and is a significant source of burden to caregivers. Prevalence rates of PSD range from 25% to 79%. The reason for treatment failure in patients of PSD includes the timing of intervention or the side effects of medications. <em>Nardostachys jatamansi</em> (D.Don) DC is commonly used in traditional medicine systems for neuropsychiatric and psychosomatic disorders with the least or no side effects. However, its clinical efficacy in PSD remains unraveled. The study aimed to evaluate the efficacy of <em>Nardostachys jatamansi</em> in PSD.</p></div><div><h3>Methods</h3><p>Present study was a double-blind randomized placebo-controlled trial with 20 patients in each test and control group. Participants were randomly allocated to receive <em>Nardostachys jatamansi</em> 3gms (powder) in the test group or placebo in the control group for six weeks. Participants were asked to follow up fortnightly for the assessment of subjective parameters. Objective parameters (Hamilton Depression Rating Scale (HDRS<sub>17</sub>) score and 36-Item Short Form Survey <strong>(</strong>SF-36) were assessed at baseline and end of the trial.</p></div><div><h3>Results</h3><p>After 6 weeks of treatment, there was a statistically significant reduction in HDRS<sub>17</sub> score and SF-36 (p < 0.001), whereas there was no significant difference in the control group (P = 0.108, and 0.29 respectively). Comparison between baseline and post-treatment scores in the test group showed a positive reduction in all subjective parameters however, in the control group there was no statistically significant change. The intergroup analysis revealed that the reduction in HDRS<sub>17</sub> score and improvement in SF-36 score was statistically significant in the test group than the control group (P < 0.001).</p></div><div><h3>Conclusion</h3><p>The study revealed that the test drug is effective in the management of PSD. There was no adverse effect observed during the trial.</p></div>\",\"PeriodicalId\":100197,\"journal\":{\"name\":\"Brain Behavior and Immunity Integrative\",\"volume\":\"2 \",\"pages\":\"Article 100012\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain Behavior and Immunity Integrative\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949834123000119\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Behavior and Immunity Integrative","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949834123000119","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Efficacy of Nardostachys jatamansi (D.Don) DC in post stroke depression: A randomized, double blind, controlled trial
Background
Post-stroke Depression (PSD) is a frequent neuropsychiatric manifestation of high clinical importance as it adversely affects recovery and quality of life, interferes with rehabilitation, and is a significant source of burden to caregivers. Prevalence rates of PSD range from 25% to 79%. The reason for treatment failure in patients of PSD includes the timing of intervention or the side effects of medications. Nardostachys jatamansi (D.Don) DC is commonly used in traditional medicine systems for neuropsychiatric and psychosomatic disorders with the least or no side effects. However, its clinical efficacy in PSD remains unraveled. The study aimed to evaluate the efficacy of Nardostachys jatamansi in PSD.
Methods
Present study was a double-blind randomized placebo-controlled trial with 20 patients in each test and control group. Participants were randomly allocated to receive Nardostachys jatamansi 3gms (powder) in the test group or placebo in the control group for six weeks. Participants were asked to follow up fortnightly for the assessment of subjective parameters. Objective parameters (Hamilton Depression Rating Scale (HDRS17) score and 36-Item Short Form Survey (SF-36) were assessed at baseline and end of the trial.
Results
After 6 weeks of treatment, there was a statistically significant reduction in HDRS17 score and SF-36 (p < 0.001), whereas there was no significant difference in the control group (P = 0.108, and 0.29 respectively). Comparison between baseline and post-treatment scores in the test group showed a positive reduction in all subjective parameters however, in the control group there was no statistically significant change. The intergroup analysis revealed that the reduction in HDRS17 score and improvement in SF-36 score was statistically significant in the test group than the control group (P < 0.001).
Conclusion
The study revealed that the test drug is effective in the management of PSD. There was no adverse effect observed during the trial.
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