{"title":"一场科学辩论:割裂DNAzyme催化研究混乱的利剑","authors":"Jiaqi Yan , Meixin Ran , Hongbo Zhang","doi":"10.1016/j.bmt.2023.01.004","DOIUrl":null,"url":null,"abstract":"<div><p>Therapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in <em>Nature Chemistry</em>, Holliger group and Chaput group had a wonderful debate base on previously reported approach for tailoring DNAzymes with high mRNA cleavage activity in mammalian cells. Their perspective pushes the catalytic mechanism investigation of DNAzymes to a new stage with more standardization and clarity.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"4 ","pages":"Pages 21-23"},"PeriodicalIF":0.0000,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research\",\"authors\":\"Jiaqi Yan , Meixin Ran , Hongbo Zhang\",\"doi\":\"10.1016/j.bmt.2023.01.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Therapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in <em>Nature Chemistry</em>, Holliger group and Chaput group had a wonderful debate base on previously reported approach for tailoring DNAzymes with high mRNA cleavage activity in mammalian cells. Their perspective pushes the catalytic mechanism investigation of DNAzymes to a new stage with more standardization and clarity.</p></div>\",\"PeriodicalId\":100180,\"journal\":{\"name\":\"Biomedical Technology\",\"volume\":\"4 \",\"pages\":\"Pages 21-23\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949723X23000041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949723X23000041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research
Therapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in Nature Chemistry, Holliger group and Chaput group had a wonderful debate base on previously reported approach for tailoring DNAzymes with high mRNA cleavage activity in mammalian cells. Their perspective pushes the catalytic mechanism investigation of DNAzymes to a new stage with more standardization and clarity.
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