Design, synthesis and molecular docking studies of 5-fluoro 1-aryl/alkyl sulfonyl benzimidazole derivatives for treatment of Parkinson’s disease

Novel sulfonyl derivatives of 5-fluoro-substituted benzimidazole were synthesized and characterized by ¹H-NMR, ¹³C-NMR, ¹⁹F-NMR and mass spectrometry. Molecular docking study against monoamine oxidase B (MAO-B), responsible for Parkinson’s disease (PD), was performed. The binding energy and interactions with active amino acid residues in the binding site of newly synthesized derivatives, as well as conventional inhibitors (Selegiline and Rasagiline), were investigated and presented. According to the docking scores predicted by ADV (AutoDock vina) and AD (AutoDock), most of the synthesized derivatives have higher binding affinity toward MAO-B than the conventional inhibitors. This study shows that these fluoro-substituted benzimidazole derivatives can be developed into essential drugs for the treatment of PD. The antibacterial property of these compounds was investigated by disk diffusion test and minimum inhibitory concentration (MIC), against gram-negative and gram-positive bacteria. And the results were further verified by the bacteria kill test with respect to time. All the synthesized compounds demonstrated considerable antibacterial activity against both bacterial strains. Therefore, this work focuses on defining the efficiency of different types of sulfonyl derivatives of fluorinated benzimidazole in biomedical research for the treatment of PD highlighting their versatile biological properties.