针对各种肺部疾病的可吸入药物输送系统的最新进展:挑战和未来展望。

Kabi Raj Chaudhary, Karanvir Singh, Charan Singh
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引用次数: 0

摘要

在目前的情况下,肺病已成为世界各地发病率和死亡率的主要负担,同时也引发了巨大的社会和经济危机。许多针对呼吸区域的传统药物递送系统和治疗方法已经被淘汰。然而,尚未实现有效和准确的恢复。在这方面,基于纳米技术的可吸入药物递送策略,包括聚合物、脂质或金属基可吸入微粒,在规避传统治疗过程中面临的众多挑战方面发挥着不可或缺的作用。优异的空气动力学性能可增强肺部靶向性,降低给药频率,从而降低全身毒性,并改善药物特性,因此药代动力学特征是与纳米技术可吸入递送相关的无休止因素。在这篇综述中,我们全面探讨了针对上述每种肺部疾病的纳米技术工程可吸入制剂的最新进展。此外,我们系统地讨论了吸入颗粒物的不确定和不确定的物理化学特征可能产生的呼吸道或全身毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Updates in Inhalable Drug Delivery System against Various Pulmonary Diseases: Challenges and Future Perspectives.

In the current scenario, pulmonary disease has become a prime burden for morbidity and mortality alongside tremendous social and economic crises throughout the world. Numerous conventional drug delivery system and treatment approach targeting the respiratory region has been driven out. However, effective and accurate recovery has not been achieved yet. In this regard, nanotechnological- based inhalable drug delivery strategy including polymeric, lipidic, or metallic-based respirable microparticles plays an indispensable role in circumventing numerous challenges faced during traditional treatment. Excellent aerodynamic performance leads to enhanced lung targetability, reduced dosing frequency and hence systemic toxicities, as well as improved pharmaceutical attributes, and therefore pharmacokinetic profiles are interminable factors associated with nanotechnologicalbased inhalable delivery. In this review, we comprehensively explored recent advancements in nanotechnologically engineered inhalable formulations targeting each of the mentioned pulmonary diseases. Moreover, we systematically discussed possible respiratory or systemic toxicities about the indeterminate and undefined physicochemical characteristics of inhaled particles.

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