内源性逆转录病毒在人体中的作用。

IF 0.5 4区医学 Q4 MICROBIOLOGY

Epidemiologie Mikrobiologie Imunologie Pub Date : 2023-01-01

M Mazúrová, P Kabát

{"title":"内源性逆转录病毒在人体中的作用。","authors":"M Mazúrová, P Kabát","doi":"","DOIUrl":null,"url":null,"abstract":"Endogenous retroviruses (ERVs) are genetic elements that were integrated into the host genome more than 100 million years ago. Their integration took place in germ cells, ensuring their vertical transmission in the human population. They are currently thought to make up to 8 % of the human genome. During evolution, various mutations have accumulated in endogenous retroviruses, leading to their dysfunction, and were therefore considered as junk DNA in the past. However, in recent years it has turned out that they are not completely dysfunctional. With more data becoming available from human genome analyses, their potential roles in the human body are being revealed.","PeriodicalId":54374,"journal":{"name":"Epidemiologie Mikrobiologie Imunologie","volume":"72 3","pages":"140-150"},"PeriodicalIF":0.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of endogenous retroviruses in the human body.\",\"authors\":\"M Mazúrová, P Kabát\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Endogenous retroviruses (ERVs) are genetic elements that were integrated into the host genome more than 100 million years ago. Their integration took place in germ cells, ensuring their vertical transmission in the human population. They are currently thought to make up to 8 % of the human genome. During evolution, various mutations have accumulated in endogenous retroviruses, leading to their dysfunction, and were therefore considered as junk DNA in the past. However, in recent years it has turned out that they are not completely dysfunctional. With more data becoming available from human genome analyses, their potential roles in the human body are being revealed.\",\"PeriodicalId\":54374,\"journal\":{\"name\":\"Epidemiologie Mikrobiologie Imunologie\",\"volume\":\"72 3\",\"pages\":\"140-150\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epidemiologie Mikrobiologie Imunologie\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiologie Mikrobiologie Imunologie","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

内源性逆转录病毒（ERV）是1亿多年前整合到宿主基因组中的遗传元素。它们的整合发生在生殖细胞中，确保了它们在人类中的垂直传播。它们目前被认为占人类基因组的8%。在进化过程中，内源性逆转录病毒中积累了各种突变，导致其功能障碍，因此在过去被认为是垃圾DNA。然而，近年来，事实证明它们并没有完全失灵。随着人类基因组分析的数据越来越多，它们在人体中的潜在作用正在被揭示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

The role of endogenous retroviruses in the human body.

Endogenous retroviruses (ERVs) are genetic elements that were integrated into the host genome more than 100 million years ago. Their integration took place in germ cells, ensuring their vertical transmission in the human population. They are currently thought to make up to 8 % of the human genome. During evolution, various mutations have accumulated in endogenous retroviruses, leading to their dysfunction, and were therefore considered as junk DNA in the past. However, in recent years it has turned out that they are not completely dysfunctional. With more data becoming available from human genome analyses, their potential roles in the human body are being revealed.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Epidemiologie Mikrobiologie Imunologie Medicine-Immunology and Allergy

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The journal publishes original papers, information from practice, reviews on epidemiological and microbiological subjects. Sufficient space is devoted to diagnostic methods from medical microbiology, parasitology, immunology, and to general aspects and discussions pertaining to preventive medicine. It also brings translations and book reviews useful for medical doctors and research workers and professionals in public health.