两个新的黄酮醇从Macaranga inermis pax和K.Hoffm。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-02-01 DOI:10.1080/14786419.2023.2272783

Mulyadi Tanjung , Tjitjik Srie Tjahjandarie , Muhammad Fajar Aldin , Shola Mardhiyyah , Ratih Dewi Saputri , Yana Maolana Syah , Norizan Ahmat

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引用次数: 0

摘要

从无叶猴的叶片中分离到四种异戊二烯基黄酮醇，包括两种新化合物，无叶猴素A-B（1-2）和两种已知化合物，华黄酮P（3），无叶棕黄酮F（4）。HRESIMS、UV、1D和2D NMR光谱的组合阐明了1-2的结构。对三种癌症细胞评价了黄酮醇（1-4）。化合物1显示出对WiDR的高细胞毒性，IC50值为0.93 µM，并且化合物2对HeLa和WiDR具有活性（IC50值为0.90和0.94 µM），并且化合物3显示出对4T1和HeLa的高活性（IC50值分别为0.83和0.98 µM）。

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Two new flavonols from Macaranga inermis pax & K.Hoffm

Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavonols (1-4) were evaluated against three cancer cells. Compound 1 showed high cytotoxicity against WiDR with an IC₅₀ value of 0.93 µM, and compound 2 was active towards HeLa and WiDR (IC₅₀ values of 0.90 and 0.94 µM), and compound 3 showed high activity towards 4T1 and HeLa (IC₅₀ values of 0.83 and 0.98 µM).

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.