合子前非整倍体部分逆转导致的合子后大脑嵌合体。

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2023-10-23 DOI:10.1038/s41588-023-01552-2

Changuk Chung, Xiaoxu Yang, Joseph G. Gleeson

引用次数: 0

摘要

大脑体细胞嵌合与多种神经系统疾病有关，并被认为是遗传后产生的。一项研究表明，先染色体非整倍体后染色体部分逆转会导致与脑嵌合相关的癫痫复发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Post-zygotic brain mosaicism as a result of partial reversion of pre-zygotic aneuploidy

查看原文本刊更多论文

Post-zygotic brain mosaicism as a result of partial reversion of pre-zygotic aneuploidy

Brain somatic mosaicism is linked to several neurological disorders and is thought to arise post-zygotically. A study suggests that pre-zygotic aneuploidy followed by post-zygotic partial reversion leads to a recurrent form of brain mosaicism-related epilepsy.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution