加纳糖尿病患者血管生成素-2与主动脉硬化相关:一项病例对照研究。

IF 2.5 Q2 PERIPHERAL VASCULAR DISEASE
International Journal of Vascular Medicine Pub Date : 2023-10-12 eCollection Date: 2023-01-01 DOI:10.1155/2023/3155982
Jennifer A Agyekum, Kwame Yeboah
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引用次数: 0

摘要

目的:血管生成受损,以血管生成生长因子的血清水平衡量,可能是糖尿病患者主动脉硬化的机制之一。我们研究了在没有任何器官损伤的2型糖尿病(T2DM)患者中主动脉硬化与循环血管生成生长因子之间的关系。方法:在病例对照设计中,测量140名T2DM患者和110名非糖尿病对照的主动脉脉搏波速度(PWV)、增宽指数(AIx)和主动脉血压(BP)。采集空腹血样以测量血管生成素-(Ang-)1、Ang-2和血管内皮生长因子-A(VEGF)的水平。结果:与非糖尿病参与者相比,T2DM患者的PWV(8.7±1.5 vs.7.6±1.3,p=0.031)、主动脉脉压(58±20 vs.49±17,p=0.011)、Ang-2(838(473-1241)vs.597(274-1005),p=0.018)增加,和VEGF(72.2(28-201.8)vs.48.4(17.4-110.1),p=0.025),但AIx水平降低(21.7±13.8 vs.34±12.9,p<0.001)和Ang-1水平降低(33.1(24.7-42.1)vs.41.1(30-57.3),p=0.01)。在所有研究参与者中,与下三分位数的参与者相比,Ang-2上三分位数参与者的PWV(2.01(1.17-3.84),p=0.004)、主动脉收缩压(1.24(1.04-1.97),p=0.011)和主动脉脉搏BP(1.19(1.04-1.82),p=0.041),但在多变量调整模型中AIx的几率降低(0.84(0.71-0.96),p=0.014)。结论:在我们的研究人群中,循环Ang-2的增加与主动脉硬化参数水平的增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Angiopoietin-2 Is Associated with Aortic Stiffness in Diabetes Patients in Ghana: A Case-Control Study.

Angiopoietin-2 Is Associated with Aortic Stiffness in Diabetes Patients in Ghana: A Case-Control Study.

Angiopoietin-2 Is Associated with Aortic Stiffness in Diabetes Patients in Ghana: A Case-Control Study.

Angiopoietin-2 Is Associated with Aortic Stiffness in Diabetes Patients in Ghana: A Case-Control Study.

Objective: Impaired angiogenesis, measured as serum levels of angiogenic growth factors, may be among the mechanisms underlining aortic stiffness in diabetes patients. We studied the association between aortic stiffness and circulating angiogenic growth factors in type 2 diabetes (T2DM) patients without any organ damage.

Methods: In a case-control design, aortic pulse wave velocity (PWV), augmentation index (AIx), and aortic blood pressures (BPs) were measured in 140 T2DM patients and 110 nondiabetic controls. Fasting blood samples were collected to measure the levels of angiopoietin- (Ang-) 1, Ang-2, and vascular endothelial growth factor-A (VEGF).

Results: Compared to nondiabetes participants, T2DM patients had increased PWV (8.7 ± 1.5 vs. 7.6 ± 1.3, p = 0.031), aortic pulse BP (58 ± 20 vs. 49 ± 17, p = 0.011), Ang-2 (838 (473-1241) vs. 597 (274-1005), p = 0.018), and VEGF (72.2 (28-201.8) vs. 48.4 (17.4-110.1), p = 0.025) but reduced levels of AIx (21.7 ± 13.8 vs. 34 ± 12.9, p < 0.001) and Ang-1 (33.1 (24.7-42.1) vs. 41.1 (30-57.3), p = 0.01). In all study participants, compared to those in the lower tertile, participants in the upper tertile of Ang-2 had increased odds of PWV (2.01 (1.17-3.84), p = 0.004), aortic systolic BP (1.24 (1.04-1.97), p = 0.011), and aortic pulse BP (1.19 (1.04-1.82), p = 0.041) but reduced odds of AIx (0.84 (0.71-0.96), p = 0.014) in multivariable-adjusted models.

Conclusion: In our study population, increased circulating Ang-2 was associated with increased levels of aortic stiffness parameters.

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来源期刊
International Journal of Vascular Medicine
International Journal of Vascular Medicine PERIPHERAL VASCULAR DISEASE-
CiteScore
3.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
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