肝酶与代谢综合征的关系：一项针对孟加拉国成年人的研究。

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM

Expert Review of Endocrinology & Metabolism Pub Date : 2023-09-01 Epub Date: 2023-11-28 DOI:10.1080/17446651.2023.2272867

Nurshad Ali, Mitu Samadder, Firoz Mahmud, Farjana Islam

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引用次数: 0

摘要

背景：本研究旨在调查孟加拉国成年人血清肝酶与代谢综合征（MetS）之间的关系。研究设计和方法：共有602名参与者（424名男性和178名女性）参加了这项横断面研究。用标准比色法测定血清肝酶（ALT、AST、GGT和ALP）水平和其他生化参数。通过多变量逻辑回归模型评估肝酶与代谢综合征之间的关系。结果：总体而言，参与者中MetS的患病率为34.9%。在四种肝酶中，患有MetS的受试者血清ALT和GGT的平均水平显著高于没有MetS的人（p p p 结论：本研究表明ALT和GGT水平升高与代谢综合征及其成分独立相关。

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Association between liver enzymes and metabolic syndrome: a study in Bangladeshi adults.

Background: This study aimed to investigate the association between serum liver enzymes and the presence of metabolic syndrome (MetS) among Bangladeshi adults.

Research design and methods: A total of 602 participants (424 males and 178 females) were enrolled in this cross-sectional study. Serum levels of liver enzymes (ALT, AST, GGT and ALP) and other biochemical parameters were measured by standard colorimetric methods. The relationship between liver enzymes and MetS was assessed by multivariable logistic regression models.

Results: Overall, the prevalence of MetS was 34.9% among the participants. Of the four liver enzymes, the mean levels of serum ALT and GGT were significantly higher among subjects with MetS than those without MetS (p < 0.01). When liver enzyme levels were categorized into normal and elevated ranges, MetS and its component's prevalence was higher in the elevated group except for ALP. Serum ALT and GGT showed a significant relationship with the maximum components of MetS. According to the logistic regression analysis, elevated levels of ALT and GGT were significantly associated with the prevalence of MetS (p < 0.01 and p < 0.001, respectively).

Conclusions: This study showed that elevated ALT and GGT levels were independently associated with MetS and its components.

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来源期刊

Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

4.80

自引率

0.00%

发文量

期刊介绍： Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.