实验室环境中透皮酒精监测装置的准确性。

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE
Eileen Brobbin, Paolo Deluca, Simon Coulton, Colin Drummond
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引用次数: 0

摘要

透皮酒精传感器(TASs)的开发提供了一种新的监测酒精消耗的方法,能够全天候客观地测量数据。我们的目的是在实验室环境中评估两种TAS(BACtrack Skyn和Smart Start BARE)的准确性。32名成年人在佩戴两个TAS时接受了0.56 g/kg体重的乙醇剂量(20%溶液),并提供了饮酒后3.5小时的呼气酒精浓度(BrAC)测量。对峰值、峰值时间和曲线下面积数据进行Pearson相关性和重复测量方差检验分析。布兰德·奥特曼的阴谋由此衍生。进行时间序列分析和互相关以调整时间滞后。两种TAS都能检测到酒精,并在20分钟内增加。BrAC的峰值明显快于Skyn和BARE。BrAC和Skyn峰呈负相关(r = -0.381,P = .035,n = 31),而Skyn和BARE峰呈正相关(r = 0.380,P = .038,n = 30)。重复测量方差分析发现BrAC、Skyn和BARE之间存在显著差异(F(1.946,852.301) = 459.873页
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Accuracy of transdermal alcohol monitoring devices in a laboratory setting.

The development of transdermal alcohol sensors (TASs) presents a new method to monitor alcohol consumption with the ability to objectively measure data 24/7. We aimed to evaluate the accuracy of two TASs (BACtrack Skyn and Smart Start BARE) in a laboratory setting. Thirty-two adults received a dose of ethanol 0.56 g/kg body weight as a 20% solution while wearing the two TASs and provided Breath Alcohol Concentration (BrAC) measurements for 3.5 h postalcohol consumption. Pearson's correlations and repeated measures analysis of variance tests were conducted on the peak, time-to-peak, and area under the curve data. Bland-Altman plots were derived. A time series analysis and cross-correlations were conducted to adjust for time lag. Both TASs were able to detect alcohol and increase within 20 min. BrAC peaked significantly quicker than Skyn and BARE. BrAC and Skyn peaks were negatively significantly correlated (r = -0.381, P = .035, n = 31), while Skyn and BARE peaks were positively significantly correlated (r = 0.380, P = .038, n = 30). Repeated measures analysis of variance found a significant difference between BrAC, Skyn, and BARE (F(1.946, 852.301) = 459.873, P < .001)). A time series analysis found when BrAC-Skyn and BrAC-BARE were adjusted for the delay to peak, and there was still a significant difference. Failure rates: 1.7% (Skyn) and 4.8% (BARE). Some evidence was obtained for TAS validity as both consistently detected alcohol. Failure rates and time lag show improvements in older device generations. However, neither TAS presented strong equivalence to the breathalyser even when the lag time was adjusted. With further testing and technology advancements, TAS could be a potential alcohol monitoring tool. Two of the newest TAS devices were worn in laboratory conditions for one afternoon to compare their accuracy of alcohol monitoring to a breathalyser. Findings suggest that the two TASs (BACtrack Skyn and SmartStart BARE) recorded significantly similar data postalcohol consumption, but not with the breathalyser.

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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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