参与行为体重控制项目的肥胖儿童白细胞端粒长度的变化。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2023-10-24 DOI:10.1111/ijpo.13082

David H. Rehkopf, Janet M. Wojcicki, K. Farish Haydel, Jue Lin, Dana L. Smith, Kristopher I. Kapphahn, Thomas N. Robinson

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引用次数: 0

摘要

目的：检测肥胖儿童行为体重控制项目期间和之后白细胞端粒长度（LTL）的变化。方法：我们测量了158名8-12岁儿童的LTL 年龄和性别的体重指数大于或等于第95百分位的年龄。儿童中55%为女性，29%为白人，52%为拉丁裔，8%为亚裔，11%为太平洋岛民，其他或多民族。所有儿童都参加了为期6个月的基于家庭的集体行为体重控制计划，并在治疗前、治疗后和1 治疗结束后一年。为了检验LTL在干预和维持时间段内的样本总体斜率，我们拟合了样条混合效应回归模型。结果：LTL平均增加0.09 T/S 单位/年（95%置信区间[CI]0.04至0.13；p = 0.0001），随后平均下降-0.05 T/S 单位/年（95%置信区间-0.08至-0.03；p 结论：肥胖儿童的LTL因行为体重控制计划而增加，这表明参与行为体重控制干预对生物健康和细胞衰老有影响。LTL可能是评估行为干预反应变化的有用生物标志物。

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Changes in leukocyte telomere length among children with obesity participating in a behavioural weight control program

Objective

To examine changes in leukocyte telomere length (LTL) during and after a behavioural weight control program for children with obesity.

Methods

We measured LTL among a cohort of 158 children 8–12 years of age with a body mass index greater than or equal to the 95th percentile for age and sex. Children were 55% female, 29% white, 52% Latinx, 8% Asian and 11% Pacific Islander, other or multiethnic. All children participated in a 6-month, family-based, group behavioural weight control program and were assessed before treatment, after treatment and 1 year after the end of treatment. To test the sample population slope of LTL over the intervention and maintenance time periods, we fit spline mixed-effect regression models.

Results

LTL increased an average of 0.09 T/S units per year (95% confidence interval [CI] 0.04 to 0.13; p = 0.0001) during the weight control program intervention period, followed by an average decline of −0.05 T/S units per year (95% CI −0.08 to −0.03; p < 0.0001) during the 1 year of follow-up after the completion of the intervention. Among 26 social, psychological, behavioural and physiological factors we examined, we did not find any predictors of these changes.

Conclusions

LTL increased in response to a behavioural weight control program among children with obesity, suggesting an impact on biological health and cellular aging from participation in a behavioural weight control intervention. LTL may be a useful biomarker for assessing changes in response to behavioural interventions.

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.