Daniela C Fuhr, Siham Sikander, Fiona Vanobberghen, Benedict Weobong, Atif Rahman, Helen A Weiss
{"title":"印度和巴基斯坦未经治疗的围产期抑郁症妇女自发缓解和恢复的预测因素。","authors":"Daniela C Fuhr, Siham Sikander, Fiona Vanobberghen, Benedict Weobong, Atif Rahman, Helen A Weiss","doi":"10.1017/gmh.2023.26","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Mothers with perinatal depression can show different symptom trajectories and may spontaneously remit from depression, however, the latter is poorly understood. This is the first study which sought to investigate predictors of spontaneous remission and longer-term recovery among untreated women with perinatal depression.</p><p><strong>Methods: </strong>We analysed data from two randomised controlled trials in women with perinatal depression in India and Pakistan. Analyses were restricted to women in the control groups who did not receive active treatment. Generalised estimating equations and logistic regressions were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for within-person correlation.</p><p><strong>Results: </strong>In multivariable analyses, remission was associated with a husband who is not working (adjusted OR, aOR = 2.04, 95% CI 1.02-4.11), lower Patient Health Questionnaire-9 score at baseline (aOR = 0.43, 95% CI 0.20-0.90 for score of ≥20 vs. 10-14) and better social support at baseline (aOR = 2.37, 95% CI 1.32-4.27 for high vs. low social support).</p><p><strong>Conclusions: </strong>Women with low baseline severity may remit from perinatal depression with adequate social support from family and friends. These factors are important contributors to the management of perinatal depression and the prevention of clinical worsening, and should be considered when designing low-threshold psychological interventions.</p>","PeriodicalId":48579,"journal":{"name":"Global Mental Health","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579649/pdf/","citationCount":"0","resultStr":"{\"title\":\"Predictors of spontaneous remission and recovery among women with untreated perinatal depression in India and Pakistan.\",\"authors\":\"Daniela C Fuhr, Siham Sikander, Fiona Vanobberghen, Benedict Weobong, Atif Rahman, Helen A Weiss\",\"doi\":\"10.1017/gmh.2023.26\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Mothers with perinatal depression can show different symptom trajectories and may spontaneously remit from depression, however, the latter is poorly understood. This is the first study which sought to investigate predictors of spontaneous remission and longer-term recovery among untreated women with perinatal depression.</p><p><strong>Methods: </strong>We analysed data from two randomised controlled trials in women with perinatal depression in India and Pakistan. Analyses were restricted to women in the control groups who did not receive active treatment. Generalised estimating equations and logistic regressions were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for within-person correlation.</p><p><strong>Results: </strong>In multivariable analyses, remission was associated with a husband who is not working (adjusted OR, aOR = 2.04, 95% CI 1.02-4.11), lower Patient Health Questionnaire-9 score at baseline (aOR = 0.43, 95% CI 0.20-0.90 for score of ≥20 vs. 10-14) and better social support at baseline (aOR = 2.37, 95% CI 1.32-4.27 for high vs. low social support).</p><p><strong>Conclusions: </strong>Women with low baseline severity may remit from perinatal depression with adequate social support from family and friends. These factors are important contributors to the management of perinatal depression and the prevention of clinical worsening, and should be considered when designing low-threshold psychological interventions.</p>\",\"PeriodicalId\":48579,\"journal\":{\"name\":\"Global Mental Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2023-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579649/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Global Mental Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1017/gmh.2023.26\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global Mental Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/gmh.2023.26","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Predictors of spontaneous remission and recovery among women with untreated perinatal depression in India and Pakistan.
Background: Mothers with perinatal depression can show different symptom trajectories and may spontaneously remit from depression, however, the latter is poorly understood. This is the first study which sought to investigate predictors of spontaneous remission and longer-term recovery among untreated women with perinatal depression.
Methods: We analysed data from two randomised controlled trials in women with perinatal depression in India and Pakistan. Analyses were restricted to women in the control groups who did not receive active treatment. Generalised estimating equations and logistic regressions were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for within-person correlation.
Results: In multivariable analyses, remission was associated with a husband who is not working (adjusted OR, aOR = 2.04, 95% CI 1.02-4.11), lower Patient Health Questionnaire-9 score at baseline (aOR = 0.43, 95% CI 0.20-0.90 for score of ≥20 vs. 10-14) and better social support at baseline (aOR = 2.37, 95% CI 1.32-4.27 for high vs. low social support).
Conclusions: Women with low baseline severity may remit from perinatal depression with adequate social support from family and friends. These factors are important contributors to the management of perinatal depression and the prevention of clinical worsening, and should be considered when designing low-threshold psychological interventions.
期刊介绍:
lobal Mental Health (GMH) is an Open Access journal that publishes papers that have a broad application of ‘the global point of view’ of mental health issues. The field of ‘global mental health’ is still emerging, reflecting a movement of advocacy and associated research driven by an agenda to remedy longstanding treatment gaps and disparities in care, access, and capacity. But these efforts and goals are also driving a potential reframing of knowledge in powerful ways, and positioning a new disciplinary approach to mental health. GMH seeks to cultivate and grow this emerging distinct discipline of ‘global mental health’, and the new knowledge and paradigms that should come from it.