吸入药效学。

IF 2 4区医学 Q3 RESPIRATORY SYSTEM

Journal of Aerosol Medicine and Pulmonary Drug Delivery Pub Date : 2023-10-01 DOI:10.1089/jamp.2023.29092.rkw

Ronald K Wolff

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引用次数: 0

摘要

药效学（PD）讨论了吸入暴露于吸入药物和有毒药物的关系。显然，帕金森病与药物动力学密切相关，这种关系可以通过吸入胰岛素来说明。PD可能与药理学反应有关，并列举了一些例子。然而，PD也可以被认为是肺部疾病状态的改善或恶化。综述了一些主要的PD终点，包括组织病理学、肺功能和支气管肺泡灌洗。还简要参考了PD反应的其他专业生物标志物。

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Inhalation Pharmacodynamics.

Pharmacodynamics (PD) is discussed in relation to inhalation exposure to inhaled pharmaceutical and toxic agents. Clearly PD is closely related to pharmacokinetics, and this relation is illustrated with reference to inhaled insulin. PD can be related to pharmacologic responses, and some examples are cited. However, PD can also be thought of as the improvement or deterioration in lung disease state. Some of the major PD endpoints, including histopathology, pulmonary function, and bronchoalveolar lavage are reviewed. Brief reference is also given to other specialty biomarkers of PD response.

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来源期刊

Journal of Aerosol Medicine and Pulmonary Drug Delivery 医学-呼吸系统

CiteScore

6.70

自引率

2.90%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.