先天性甲状腺功能减退新生儿一级亲属甲状腺功能减退:有关联吗?

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of Preventive Medicine Pub Date : 2023-08-28 eCollection Date: 2023-01-01 DOI:10.4103/ijpvm.ijpvm_339_22
Maryam Heidarpour, Sepehr Omoomi, Omid Vakilbashi, Azin Taki, Silva Hovsepian
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引用次数: 0

摘要

背景:最近的研究表明,先天性甲状腺功能减退症(CH)的发病率增加,尤其是在中东部地区。确切病因尚不清楚;然而,它与几个因素有关,最引人注目的是短暂性CH(TCH)的高患病率、父母的血缘关系和亲属的甲状腺功能减退史。我们试图通过观察到的趋势来确定甲状腺功能减退对患者亲属的影响。方法:我们纳入了2007年至2016年通过新生儿筛查(NBS)计划检测到的所有原发性CH患者。我们分析了血缘关系、父母和兄弟姐妹的甲状腺功能、二级亲属的甲状腺功能,父母的教育水平、年龄和母亲妊娠期糖尿病对永久性CH(PCH)和TCH发展的影响。结果:在研究期间,共招募了1447名连续符合条件的患者。在这一数字中,1171人(81%)被诊断为CH:623人(53.2%)患有PCH,548人(46.8%)患有TCH。633名(54.1%)参与者是男性,814名(69.5%)有亲属甲状腺功能减退史。我们的数据分析显示,与TCH相比,男性、有亲属甲状腺功能减退史和父母甲状腺功能减退症有显著差异(P<0.05)。有亲属甲状腺机能减退史的患者的PCH显著高于TCH(P<0.0001)。然而,无论其亲属是否有甲状腺功能减退史,患者的近亲婚姻都不具有可比性(P值>0.884)。结论:我们的研究结果表明,新生儿亲属的甲状腺功能减退病史在PCH的演变中起着重要作用。同时,近亲结婚对PCH和TCH的发展没有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypothyroidism in First-Degree Relatives of Neonates with Congenital Hypothyroidism: Is there an Association?

Background: Recent studies have shown an increased incidence of congenital hypothyroidism (CH), especially in the middle-east region. The exact etiology is unknown; however, it has been related to several factors, the most noticeable being the high prevalence of transient CH (TCH), parental consanguinity, and the history of hypothyroidism in relatives. We sought to determine the impact of hypothyroidism in the relatives of patients with the observed trend.

Methods: We included all patients with primary CH detected through the Newborn Screening (NBS) Program from 2007 to 2016. We analyzed the impact of consanguinity relationship, parental and siblings' thyroid function, second-degree relatives' thyroid function, parental educational level, age, and maternal gestational diabetes on the development of permanent CH (PCH) and TCH.

Results: A total of 1447 consecutive eligible patients were recruited during the study period. Of this number, 1171 (81%) were diagnosed with CH: 623 (53.2%) had PCH and 548 (46.8%) had TCH. Six hundred thirty-three (54.1%) participants were men, and 814 (69.5%) had a history of relatives' hypothyroidism. Our data analysis revealed a significant difference regarding the male gender, having a history of relatives' hypothyroidism, and parental hypothyroidism compared to TCH ones (P < 0.05). Patients with a history of relatives' hypothyroidism had significantly higher PCH than TCH (P < 0.0001). However, consanguineous marriage was not comparable in patients regardless of their history of relatives' hypothyroidism (P-value >0.884).

Conclusions: Our findings indicated the role of the history of hypothyroidism in neonates' relatives in the evolution of the PCH. Meanwhile, consanguineous marriage did not impress the development of PCH and TCH.

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来源期刊
International Journal of Preventive Medicine
International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
4.80%
发文量
107
期刊介绍: International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.
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