Jiawen Liao, Yi Zhang, Zhenchun Yang, Chenyu Qiu, Wu Chen, Junfeng Jim Zhang, Kiros Berhane, Zhipeng Bai, Bin Han, Jia Xu, Yong-Hui Jiang, Frank Gilliland, Weili Yan, Guoying Huang, Zhanghua Chen
{"title":"确定孕前和妊娠期空气污染暴露对出生体重的关键窗口：一项前瞻性队列研究。","authors":"Jiawen Liao, Yi Zhang, Zhenchun Yang, Chenyu Qiu, Wu Chen, Junfeng Jim Zhang, Kiros Berhane, Zhipeng Bai, Bin Han, Jia Xu, Yong-Hui Jiang, Frank Gilliland, Weili Yan, Guoying Huang, Zhanghua Chen","doi":"10.1186/s12940-023-01022-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Few studies have assessed air pollution exposure association with birthweight during both preconception and gestational periods.</p><p><strong>Methods: </strong>Leveraging a preconception cohort consisting of 14220 pregnant women and newborn children in Shanghai, China during 2016-2018, we aim to assess associations of NO<sub>2</sub> and PM<sub>2.5</sub> exposure, derived from high-resolution spatial-temporal models, during preconception and gestational periods with outcomes including term birthweight, birthweight Z-score, small-for-gestational age (SGA) and large-for-gestational age (LGA). Linear and logistic regressions were used to estimate 3-month preconception and trimester-averaged air pollution exposure associations; and distributed lag models (DLM) were used to identify critical exposure windows at the weekly resolution from preconception to delivery. Two-pollutant models and children's sex-specific associations were explored.</p><p><strong>Results: </strong>After controlling for covariates, one standard deviation (SD) (11.5 μg/m<sup>3</sup>, equivalent to 6.1 ppb) increase in NO<sub>2</sub> exposure during the second and the third trimester was associated with 13% (95% confidence interval: 2 - 26%) and 14% (95% CI: 1 - 29%) increase in SGA, respectively; and one SD (9.6 μg/m<sup>3</sup>) increase in PM<sub>2.5</sub> exposure during the third trimester was associated with 15% (95% CI: 1 - 31%) increase in SGA. No association have been found for outcomes of birthweight, birthweight Z-score and LGA. DLM found that gestational weeks 22-32 were a critical window, when NO<sub>2</sub> exposure had strongest associations with SGA. The associations of air pollution exposure tended to be stronger in female newborns than in male newborns. However, no significant associations of air pollution exposure during preconception period on birthweight outcomes were found.</p><p><strong>Conclusion: </strong>Consistent with previous studies, we found that air pollution exposure during mid-to-late pregnancy was associated with adverse birthweight outcomes.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":8.3000,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585741/pdf/","citationCount":"0","resultStr":"{\"title\":\"Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.\",\"authors\":\"Jiawen Liao, Yi Zhang, Zhenchun Yang, Chenyu Qiu, Wu Chen, Junfeng Jim Zhang, Kiros Berhane, Zhipeng Bai, Bin Han, Jia Xu, Yong-Hui Jiang, Frank Gilliland, Weili Yan, Guoying Huang, Zhanghua Chen\",\"doi\":\"10.1186/s12940-023-01022-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Few studies have assessed air pollution exposure association with birthweight during both preconception and gestational periods.</p><p><strong>Methods: </strong>Leveraging a preconception cohort consisting of 14220 pregnant women and newborn children in Shanghai, China during 2016-2018, we aim to assess associations of NO<sub>2</sub> and PM<sub>2.5</sub> exposure, derived from high-resolution spatial-temporal models, during preconception and gestational periods with outcomes including term birthweight, birthweight Z-score, small-for-gestational age (SGA) and large-for-gestational age (LGA). Linear and logistic regressions were used to estimate 3-month preconception and trimester-averaged air pollution exposure associations; and distributed lag models (DLM) were used to identify critical exposure windows at the weekly resolution from preconception to delivery. Two-pollutant models and children's sex-specific associations were explored.</p><p><strong>Results: </strong>After controlling for covariates, one standard deviation (SD) (11.5 μg/m<sup>3</sup>, equivalent to 6.1 ppb) increase in NO<sub>2</sub> exposure during the second and the third trimester was associated with 13% (95% confidence interval: 2 - 26%) and 14% (95% CI: 1 - 29%) increase in SGA, respectively; and one SD (9.6 μg/m<sup>3</sup>) increase in PM<sub>2.5</sub> exposure during the third trimester was associated with 15% (95% CI: 1 - 31%) increase in SGA. No association have been found for outcomes of birthweight, birthweight Z-score and LGA. DLM found that gestational weeks 22-32 were a critical window, when NO<sub>2</sub> exposure had strongest associations with SGA. The associations of air pollution exposure tended to be stronger in female newborns than in male newborns. 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Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.
Background: Few studies have assessed air pollution exposure association with birthweight during both preconception and gestational periods.
Methods: Leveraging a preconception cohort consisting of 14220 pregnant women and newborn children in Shanghai, China during 2016-2018, we aim to assess associations of NO2 and PM2.5 exposure, derived from high-resolution spatial-temporal models, during preconception and gestational periods with outcomes including term birthweight, birthweight Z-score, small-for-gestational age (SGA) and large-for-gestational age (LGA). Linear and logistic regressions were used to estimate 3-month preconception and trimester-averaged air pollution exposure associations; and distributed lag models (DLM) were used to identify critical exposure windows at the weekly resolution from preconception to delivery. Two-pollutant models and children's sex-specific associations were explored.
Results: After controlling for covariates, one standard deviation (SD) (11.5 μg/m3, equivalent to 6.1 ppb) increase in NO2 exposure during the second and the third trimester was associated with 13% (95% confidence interval: 2 - 26%) and 14% (95% CI: 1 - 29%) increase in SGA, respectively; and one SD (9.6 μg/m3) increase in PM2.5 exposure during the third trimester was associated with 15% (95% CI: 1 - 31%) increase in SGA. No association have been found for outcomes of birthweight, birthweight Z-score and LGA. DLM found that gestational weeks 22-32 were a critical window, when NO2 exposure had strongest associations with SGA. The associations of air pollution exposure tended to be stronger in female newborns than in male newborns. However, no significant associations of air pollution exposure during preconception period on birthweight outcomes were found.
Conclusion: Consistent with previous studies, we found that air pollution exposure during mid-to-late pregnancy was associated with adverse birthweight outcomes.
期刊介绍：
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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