不同取代吡唑衍生物的不同药理潜力。

IF 1.7 4区 化学 Q3 CHEMISTRY, ORGANIC
Mohammad Asif, Mazen Almehmadi, Ahad Amer Alsaiari, Mamdouh Allahyani
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引用次数: 0

摘要

杂环化合物的化学一直是一个研究热点。一些五元杂环化合物由于其不同类型的药理作用而成为广泛研究的主题。五元含氮杂环化合物吡唑、吡唑啉和吡唑酮衍生物由于其不同的治疗活性而在医学和农业化学领域引起了广泛的兴趣。各种取代的吡唑、吡唑啉和吡唑啉酮化合物表现出多种药理作用,如抗微生物、抗炎、抗结核、抗真菌、抗疟疾、抗糖尿病、利尿、抗抑郁、抗惊厥、抗氧化、抗利什曼原虫、抗糖尿病和抗病毒等,吡唑啉酮衍生物通过不同的合成方法以及对其化学和生物行为的研究变得越来越重要。综述了吡唑、吡唑啉和吡唑酮衍生物的合成方法,这些化合物具有重要的生物学性质,具有广泛的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diverse Pharmacological Potential of different Substituted Pyrazole Derivatives.

The chemistry of heterocyclic compounds has been a topic of research interest. Some five-membered heterocyclic compounds have been the subject of extensive research due to their different types of pharmacological effects. The five-membered nitrogen-containing heterocyclic compounds pyrazole, pyrazoline, and pyrazolone derivatives have a lot of interest in the fields of medical and agricultural chemistry due to their diverse spectrum of therapeutic activities. Various substituted pyrazole, pyrazoline, and pyrazolone compounds exhibited diverse pharmacological effects like Anti-microbial, anti-inflammatory, anti-tubercular, anti-fungal, anti-malarial, anti-diabetic, diuretic, anti-depressant, anticonvulsant, antioxidant, anti-leishmanial, antidiabetic, and antiviral, etc. In recent decades, the synthesis of numerous pyrazole, pyrazoline, and pyrazolone derivatives by different synthetic methods as well as research into their chemical and biological behavior have become more important. This review focuses on synthetic methods of the pyrazole, pyrazoline, and pyrazolone derivatives, which have significant biological properties and a variety of applications.

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来源期刊
Current organic synthesis
Current organic synthesis 化学-有机化学
CiteScore
3.40
自引率
5.60%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Current Organic Synthesis publishes in-depth reviews, original research articles and letter/short communications on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.
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