{"title":"芯片工程骨髓","authors":"Y. Torisawa","doi":"10.21037/MPS.2019.02.01","DOIUrl":null,"url":null,"abstract":"Bone marrow is the permanent hematopoietic organ; the main function is to produce blood cells for the body through life. The microenvironment of bone marrow contains a complex set of cellular, chemical, and physical signals to maintain the hematopoietic system (1-3). The hematopoietic niche regulates hematopoietic stem cells (HSCs) to facilitate a balance between self-renewal and differentiation into progenitor cells that produce all types of blood cells.","PeriodicalId":87327,"journal":{"name":"Microphysiological systems","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/MPS.2019.02.01","citationCount":"2","resultStr":"{\"title\":\"Engineering bone marrow-on-a-chip\",\"authors\":\"Y. Torisawa\",\"doi\":\"10.21037/MPS.2019.02.01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Bone marrow is the permanent hematopoietic organ; the main function is to produce blood cells for the body through life. The microenvironment of bone marrow contains a complex set of cellular, chemical, and physical signals to maintain the hematopoietic system (1-3). The hematopoietic niche regulates hematopoietic stem cells (HSCs) to facilitate a balance between self-renewal and differentiation into progenitor cells that produce all types of blood cells.\",\"PeriodicalId\":87327,\"journal\":{\"name\":\"Microphysiological systems\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.21037/MPS.2019.02.01\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microphysiological systems\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21037/MPS.2019.02.01\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microphysiological systems","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21037/MPS.2019.02.01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Bone marrow is the permanent hematopoietic organ; the main function is to produce blood cells for the body through life. The microenvironment of bone marrow contains a complex set of cellular, chemical, and physical signals to maintain the hematopoietic system (1-3). The hematopoietic niche regulates hematopoietic stem cells (HSCs) to facilitate a balance between self-renewal and differentiation into progenitor cells that produce all types of blood cells.