基于免疫调节的金属软组织植入物开发工程

Q1 Engineering
Shoucheng Chen , Jiamin Shi , Guangqi Gao , Lv Xie, Yingye Zhang, Zhengjie Shan, Zhuwei Huang, Xinchun Zhang, Zhuofan Chen, Zetao Chen
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引用次数: 1

摘要

金属材料因其优越的力学性能在临床上得到了广泛的应用。然而,金属植入物与周围软组织的整合仍然具有挑战性,可能导致严重的感染和治疗失败。自然样本的发展表明,硬表面周围软组织整合的建立是一个复杂的场景,与上皮组织、结缔组织和免疫细胞的协调有关。此外,种植体周围免疫微环境对软组织整合修复过程的影响也越来越受到关注。鉴于金属种植体的特性可以有效地调节免疫反应,调节金属种植体周围的免疫微环境以优化软组织整合是可以预见的。本文首先比较了天然生物硬表面-软组织整合体与金属植入体的建立,强调了上皮组织、结缔组织和免疫细胞在其中的重要作用。此外,对免疫微环境与软组织整合密切相关的最新研究成果进行了讨论和总结。从软硬组织的自然融合发展和修复过程出发,提出了基于免疫调节的策略来操纵免疫微环境以增强软组织-金属种植体的融合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunomodulation-based development engineering for advancing metal soft tissue implants

Metal materials have been widely applied clinically due to their superior mechanical properties. However, the integration of metallic implants with surrounding soft tissue remains challenging and may lead to severe infections and failure of treatments. Development of natural exemplar suggests that the establishment of the soft tissue integration around hard surfaces is a complex scenario associated with the coordination of epithelial tissue, connective tissue and immune cells. In addition, the influence of the peri-implant immune microenvironment on soft tissue integration reparative process has received increasing attention. Given that the properties of the metal implant could effectively modulate immune response, it is predictable to regulate the immune microenvironment around metal implants for optimized soft tissue integration. This review firstly compared the establishment of natural biological hard surface-soft tissue integration with metal implants, in which the important role of epithelial tissue, connective tissue and immune cells were emphasized. Furthermore, up-to-date research outcomes in the closely connections between the immune microenvironment and soft tissue integration were discussed and summarized. From the view of natural soft-hard tissue integration development and reparative process, the immunomodulation-based strategy is proposed to manipulate the immune microenvironment for the enhancement of soft tissue-metal implant integration.

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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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