人类基因编辑之争

IF 1.4 Q2 ETHICS

New Bioethics-A Multidisciplinary Journal of Biotechnology and the Body Pub Date : 2022-09-19 DOI:10.1080/20502877.2022.2117516

T. Stammers

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引用次数: 0

摘要

（第21页）−用于治疗囊性纤维化的药物Ivacaftor不会“产生缺失的[CFTR]蛋白”（正如利兹大学David Packham教授所说）。该药物是一种复杂的酚类化合物，与有缺陷的通道蛋白结合，迫使离子通道打开（第24页）−可遗传基因组编辑目前是通过编辑受精卵（单细胞胚胎）的基因组而不是卵子和精子来实现的。由受精卵发育而成的成年人产生的卵子或精子将携带编辑（第49页）−艾滋病毒不是一种可遗传的疾病（第50页）−疟疾不是由病毒引起的，而是由蚊子传播的原生生物引起的。（第93页）

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The Human Gene Editing Debate

(p. 21) − The drug Ivacaftor, used as a treatment for cystic fibrosis, does not ‘produce the missing [CFTR] protein’ (as stated by Professor David Packham, Leeds University). The drug is a complex phenolic compound that binds to the defective channel protein, forcing the ion channel to open (p. 24) − Heritable genome editing is currently achieved by editing the genome of the zygote (one-cell embryo) not the eggs and sperm. The eggs or sperm produced by the adult that develops from the zygote will carry the edit (p. 49) − HIV is not a heritable disease (p.50) − Malaria is not caused by a virus but by a mosquito-transmissible protist. (p. 93)

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来源期刊

New Bioethics-A Multidisciplinary Journal of Biotechnology and the Body ETHICS-

CiteScore

2.30

自引率

16.70%

发文量