环境对原发性干燥综合征干眼症的影响

IF 0.1 Q4 OPHTHALMOLOGY
Joo Ye Park, H. Paik, Dong Hyun Kim
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引用次数: 0

摘要

目的:研究湿度、温度和细颗粒物(PM2.5)对原发性干燥综合征患者干眼病(DED)参数的影响。方法:我们回顾性分析了18例原发性干燥综合征患者的医疗记录,这些患者接受了DED治疗并进行了两次以上的随访。评估干眼症状评估(SANDE)评分、泪液分泌、泪膜破裂次数、眼表染色评分和泪液渗透压。使用公共数据计算患者就诊前一周的温度、湿度和PM2.5浓度,并分析它们与DED参数的关系。结果:所有患者均为女性,平均年龄57.6±12.4岁。高温与湿度和PM2.5浓度显著相关(分别为p=0.004和=0.006)。高湿度、高温和低PM2.5组的SANDE评分较低(分别为p=0.017、=0.063和=0.049)和泪液渗透压(分别为p<0.001、=0.009和<0.001)。多元回归分析表明,与PM2.5浓度相比,温度和湿度与泪液渗透压的相关性更强(分别为0.005和0.012)。结论:眼部不适和泪液渗透压与温度、湿度和PM2.5浓度有关。在DED参数中,泪液渗透压是暴露于环境因素的最敏感指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Environmental Effects on Dry Eyes in Primary Sjogren's Syndrome
Purpose: To investigate the effects of humidity, temperature, and fine particulate matter (PM2.5) on dry eye disease (DED) parameters in primary Sjogren's syndrome patients.Methods: We retrospectively analyzed the medical records of 18 primary Sjogren's syndrome patients who underwent DED treatment and had more than two follow-up visits. Symptom Assessment in Dry Eye (SANDE) scores, tear secretion, tear film breakup times, ocular surface staining scores, and tear osmolarity were assessed. Temperature, humidity, and PM2.5 concentrations during the week before the patient visits were calculated using public data and their relationships with DED parameters were analyzed.Results: All patients were females, with an average age of 57.6 ± 12.4 years. High temperature was significantly correlated with humidity and PM2.5 concentration (p = 0.004 and = 0.006, respectively). The high humidity, high temperature, and low PM2.5 groups had lower SANDE scores (p = 0.017, = 0.063, and = 0.049, respectively) and tear osmolarity (p < 0.001, = 0.009, and < 0.001, respectively). Multiple regression analysis showed that temperature and humidity had stronger correlations with tear osmolarity (p = 0.005 and = 0.012, respectively) compared to PM2.5 concentrations.Conclusions: Ocular discomfort and tear osmolarity were correlated with temperature, humidity, and PM2.5 concentrations. Among the DED parameters, tear osmolarity was the most sensitive indicator of exposure to environmental factors.
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CiteScore
0.20
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