纳米乳液:一种更智能的局部脂质乳液纳米载体

IF 0.8 4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES
Suraj Mandal, Prabhakar Vishvakarma
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引用次数: 0

摘要

在过去的几十年里,研究人员投入了大量的时间和精力来制造新药。因此,现在有大量的药理学化学物质可以用于治疗医疗系统面临的一系列问题。这些药物中超过50%被归类为BCS(生物制药分类系统)II/IV类,这表明它们的治疗价值有限,没有进一步研究。通过这种方式,已经表明脂质体制造是分销这些药物的好方法。这表明基于纳米技术的方法有很大的潜力。纳米乳化凝胶是一种由多种纳米类脂成分组成的凝胶,已被证明是一种有效的局部用药方法。纳米乳液凝胶是一种基于乳液的局部凝胶产品。将正确的胶凝成分添加到使用高能或低能工艺制成的乳液球中,以形成纳米乳液凝胶。纳米乳液可以由各种聚合物、表面活性剂和脂肪制成,尺寸从5纳米到500纳米不等。纳米乳胶凝胶有几种短期和长期问题的局部治疗方法。最近获得专利的药物的纳米乳液制剂在各种医疗环境中的广泛使用再次表明,局部给药比其他方法更好。然而,对这些配方中使用的化学物质的毒理学研究必须考虑到它们的安全性,因为它们的给药方式已经发生了很大变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanoemulgel: A Smarter Topical Lipidic Emulsion-based Nanocarrier
In the last few decades, researchers have put a lot of time and effort into making new pharmaceuticals. As a result, there are now a huge number of pharmacological chemicals that can be used to treat a wide range of diseases that are a problem for the healthcare system. More than 50% of these medications are classed as BCS (Biopharmaceutical Classification System) class II/IV, indicating that they have limited therapeutic value and are not further studied. In this way, it has been shown that lipoidal manufacturing is a good way to distribute these kinds of medicines. This suggests that a method based on nanotechnology has a lot of potential. Nanoemulgel, a gel composed of diverse nano-lipoidal compositions, has been shown to be an effective method for applying topical drugs. Nanoemulgel is an emulsion-based topical gel product. The correct gelling ingredient is added to emulsion globules made using high energy or low energy processes to form nanoemulgel. Nanoemulgels can be made from all kinds of polymeric polymers, surfactants, and fats that range in size from 5 nm to 500 nm. Nanoemulgel has several topical treatments for both short-term and long-term problems. The widespread use of nanoemulgel formulations of recently patented drugs in a variety of healthcare settings has once again shown that topical administration is better than other methods. Toxicological studies of the chemicals used in these formulations must, however, take into account how safe they are, since the way they are given has changed a lot.
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
227
审稿时长
>12 weeks
期刊介绍: The official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967. IJPER, a quarterly publication devoted to publish reviews and research articles in pharmacy and the related disciplines of Pharmaceutical education. It mainly covers the articles of special interest, covering the areas of Pharmaceutical research, teaching and learning, laboratory innovations, education technology, curriculum design, examination reforms, training and other related issues. It encourages debates and discussions on the issues of vital importance to Pharmaceutical education and research. The goal of the journal is to provide the quality publications and publish most important research and review articles in the field of drug development and pharmaceutical education. It is circulated and referred by more than 6000 teachers, 40,000 students and over 1000 professionals working in Pharmaceutical industries, Regulatory departments, hospitals etc.
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