围产期窒息新生儿急性肾损伤的早期预测

IF 0.3 Q4 PEDIATRICS
N. Refat, Mohamed Amir Fathy, Ali Hamdy Ali Abdel Hafez, Mohammed Abdeltawab Sabra, E. Hamed, Y. F. Abdelraheem
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引用次数: 0

摘要

摘要急性肾损伤(AKI)是新生儿死亡的独立危险因素。由于新生儿早期肾损伤通常没有特定的临床症状,如果没有相关检查,许多AKI病例往往错过了早期干预的最佳时间。围产期窒息(PA)可导致AKI。该研究旨在评估血清胱抑素C(Cysc)在足月PA新生儿AKI早期预测中的疗效。该研究于2019年1月至2021年1月在阿西乌大学儿童医院新生儿重症监护室进行。研究纳入了70名有PA记录的足月新生儿。评估基线实验室数据和血清半胱氨酸蛋白酶C水平。在70名患有PA的新生儿中,21名(30%)出现AKI,49名(70%)新生儿没有出现AKI。非AKI组大多为I期缺氧缺血性脑病(HIE)(61.2%),而AKI组大多数为III期HIE(61.9%) ± 0.12对0.90 ± 0.14,p < PA新生儿AKI的预测因素为低出生体重、血清半胱氨酸蛋白酶C水平、低血压和III期HIE。血清半胱氨酸蛋白酶抑制剂对AKI的预测总体准确率为94.3%。总之,患有PA的新生儿AKI是常见的。在这种情况下,半胱氨酸蛋白酶抑制剂是早期预测AKI的一种很有前途的生物标志物。未来的研究有必要证实这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early Predictor of Acute Kidney Injury in Newborns with Perinatal Asphyxia
Abstract Acute kidney injury (AKI) is an independent risk factor for neonatal death. Since neonatal early renal injury usually has no specific clinical symptoms, many AKI cases are often missed the best time of early intervention if there is no relevant examination. Perinatal asphyxia (PA) can lead to AKI. The study aimed to assess efficacy of serum cystatin C (CystC) in early prediction of AKI in full-term neonates with PA. The study was conducted at the neonatal intensive care unit, Assiut University Children Hospital from January 2019 to January 2021. Seventy full-term neonates with documented PA were enrolled in the study. Baseline laboratory data and serum CystC levels were assessed. Out of those 70 neonates with PA, 21 (30%) developed AKI, while 49 (70%) neonates did not develop AKI. Majority of non-AKI group had stage-I hypoxic-ischemic encephalopathy (HIE) (61.2%), while majority of AKI had stage-III HIE (61.9%). A significantly higher serum CystC level was found among AKI group than those without AKI (1.50 ± 0.12 vs. 0.90 ± 0.14, p  < 0.001). The predictors for AKI among neonates with PA were low birth weight, serum CystC levels, hypotension, and stage-III HIE. Serum CystC has 94.3% overall accuracy for prediction of AKI. In conclusion, AKI in neonates with PA is common. CystC is a promising biomarker in early prediction of AKI in such cases. Future studies are warranted to confirm these findings.
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