l -精氨酸生物合成一氧化氮。一氧化氮的形成特征及其在线粒体中的功能作用

Q4 Biochemistry, Genetics and Molecular Biology

Ukrainian Biochemical Journal Pub Date : 2018-02-25 DOI:10.15407/UBJ90.01.003

G. V. Danylovych, T. V. Bohach, Yuriy V. Danylovych

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引用次数: 5

摘要

描述了在常氧条件下哺乳动物细胞从l-精氨酸生物合成一氧化氮的生物化学模式的现代数据。近年来对一氧化氮合酶异构体的结构和调控特性的研究结果引起了作者的注意。重点是这些酶的某些亚型在细胞中的区室化的最新概念，以及一氧化氮在血管壁中定向转运的可能性。综述的中心位置致力于线粒体中NO的内源性形成及其潜在的生理意义。我们对子宫平滑肌线粒体中NO的鉴定、这一过程的生化特征以及NO在细胞器调节Са2+转运中的可能作用进行了介绍和讨论。

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The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria

Modern data on biochemical patterns of nitric oxide biosynthesis in mammal cells from l-arginine in normoxic conditions is described. The attention of the authors is given to the results of the recent years on the structure and regulation features isoforms of No-synthase. The emphasis is put on the latest conception of the compartmentalization of certain isoforms of these enzymes in cells and on the possibility of the directed transport of nitric oxide in the vascular wall. The central place in the review is devoted to issues on the endogenous formation of NO in mitochondria and its potential physiological significance. Our own results on the identification of NO in mitochondria of the uterine smooth muscle, biochemical characteristics of this process and NO possible role in Са2+ transport regulation by organelles are presented and discussed.

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来源期刊

Ukrainian Biochemical Journal Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： The Ukrainian Biochemical Journal publishes original research papers, reviews and brief notes; papers on research methods and techniques; articles on the history of biochemistry, its development and prominent figures; discussion articles; book reviews; chronicles; etc. The journal scope includes not only biochemistry but also related sciences, such as cellular and molecular biology, bioorganic chemistry, biophysics, pharmacology, genetics, and medicine (medical biochemistry et al.) – insofar as the studies use biochemical methods and discuss biochemical findings.