雨红球藻虾青素对创伤溃疡模型中直径的影响

Anastasia Natasa Aripin, Dwi Andriani, M. Ashrin
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引用次数: 0

摘要

引言:印度尼西亚创伤性溃疡的患病率很高(96.6%)。虾青素来源于绿色微藻红球藻,由于其强大的抗氧化和抗炎作用,是溃疡愈合的替代治疗方法之一。本研究旨在分析虾青素对创伤溃疡模型中第1天和第3天溃疡直径差异的有效性。方法:将30只Wistar大鼠随机分为5组,分别治疗外伤性溃疡,治疗3天;K+(透明质酸对照组);P1(施用0.1%虾青素);P2(施用0.5%虾青素);P3(施用1%虾青素)。然后用单向ANOVA检验对数据结果进行分析,Post-Hoc LSD检验的结果为p=0,05。结果:使用单向方差分析的统计参数检验显示,第1天和第3天的直径溃疡有显著差异(p<0.05)。事后LSD测试显示,与K+(2297±1045)、P1(1740±1168)、P2(1993±0738)和P3(2448±1320)相比,K-(5300±2832)之间存在显著差异(p<0.05)。结论:给予虾青素凝胶有减少创伤溃疡愈合过程中第1天和第3天溃疡直径差异的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efek pemberian astaxanthin (Haematococcus pluvialis) terhadap ukuran diameter pada model ulkus traumatikusThe effect of astaxanthin (Haematococcus pluvialis) on diameter measurement in traumatic ulcer model
Introduction: The prevalence of traumatic ulcers in Indonesia is high (96,6%). Astaxanthin, derived from the green microalgae Haematococcus Pluvialis, is one of the alternative treatments for ulcer healing due to its potent antioxidant and anti-inflammatory effect. This study aimed to analyze astaxanthin’s effectiveness on the difference in the diameter of the ulcer on day 1 and day 3 in a traumatic ulcer model. Methods: Samples of 30 Wistar rats were randomly divided into 5 groups which were treated with traumatic ulcers and then treated for 3 days according to their respective groups: K-(control group given gel base); K+ (control group given hyaluronic acid); P1 (application of 0.1% astaxanthin); P2 (application of 0.5% astaxanthin); P3 (application of 1% astaxanthin). The data results were then carried out with one way ANOVA test, and the Post Hoc LSD test proceeded with p=0,05. Results: The statistical parametric test using One Way ANOVA showed a significant difference (p<0,05) in the diameter ulcer on day 1 and day 3. Post Hoc LSD test showed a significant difference (p<0,05) between K-(5,300 ± 2,832) compare to K+ (2,297 ± 1,045), P1(1,740 ± 1,168), P2(1,993 ± 0,738), and P3 (2,448 ± 1,320). Conclusions: There is an effect of giving astaxanthin gel in reducing the difference in the diameter of the ulcer on day 1 and day 3 on the healing process of traumatic ulcer.
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