半乳甘露聚糖和β- d -葡聚糖对小麦车间职业性哮喘的潜在诊断作用

Safaa Elserougy , Safia Beshir , Mohamed El-Gewily , Mustafa El-Husseini , Salwa Hafez , Mohamed El-Hamshary
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摘要

职业性哮喘被定义为由于暴露于工作场所环境中的特定物质而引起的可变气道阻塞。本研究旨在了解小麦碾磨工人职业性哮喘的发病频率,并探讨真菌生物标志物半乳甘露聚糖(GM)和β- d -葡聚糖(βDG)在职业性哮喘中的作用。对象和方法:对空气中真菌进行了评价。对120名工人(n=120)在吸入沙丁胺醇前和15分钟及夜间的肺活量测定功能进行了评估。分析血样,测定血清GM、βDG和过敏原特异性免疫球蛋白e。结果与结论:有相当比例的工人患有职业性哮喘(25%),只有4名工人(3.3%)患有非职业性哮喘(排除在本研究之外)。其余都是正常人(86名)。空气环境中仅发现青霉和曲霉。职业性哮喘患者的GM平均浓度(GM-c)明显高于正常工人。高GM-c (1 pg/ml)的工人患职业性哮喘的风险(优势比)高出13.3倍。Ln (GM)是PEFR变异性的唯一显著预测因子。GM在小麦加工厂工人因真菌暴露引起的职业性哮喘中具有潜在的诊断作用。β - dg在职业性哮喘中无作用。建议面粉厂工人每6 ~ 12个月定期进行肺功能测定和血清GM检测,以早期诊断和控制职业性哮喘。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Potential diagnostic role of galactomannan and β-D-glucan in occupational asthmatics in wheat mills

Potential diagnostic role of galactomannan and β-D-glucan in occupational asthmatics in wheat mills

Occupational asthma is defined as variable airway obstruction due to exposure to a specific substance in the workplace environment. The aim of the study was to find out the frequency of occupational asthma in wheat mill workers and to explore the role of fungi biomarkers (galactomannan (GM) and β-D-glucan (βDG)) in occupational asthma. Subjects and methods: Assessment of fungi in air was done. Spirometric function of workers (n=120) were assessed during diurnal (before and 15 minutes after inhalation of salbutamol) and nocturnal time. Blood samples were analyzed to measure serum GM and βDG and allergen specific immunoglobulin E. The workers were asked about asthma symptoms. Results and conclusion: A significant proportion of workers had occupational asthma (25%) and only four workers (3.3%) had non-occupational asthma (excluded from the study). The rest were normal (86 workers). Penicillium and Aspergillus were the only species found in the air environment. Mean GM concentration (GM-c) was significantly higher among occupational asthmatics than normal workers. The estimated risk of occupational asthma (Odds ratio) was 13.3 times higher among workers with high GM-c (>1 pg/ml). Ln (GM) was the only significant predictor of PEFR variability. GM has a potential diagnostic role in occupational asthma due to fungal exposure among wheat mill workers. βDG did not have a role in occupational asthma. We recommend that wheat mill flour workers should do periodic spirometric functions and serum GM every 6 - 12 months for early diagnosis and control of occupational asthma.

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Hygiene and environmental health advances
Hygiene and environmental health advances Environmental Science (General)
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