高效液相色谱法同时测定雷公藤根、茎、叶中大环亚精胺生物碱的含量

IF 1.7 4区化学 Q3 CHEMISTRY, ANALYTICAL

Acta Chromatographica Pub Date : 2022-03-23 DOI:10.1556/1326.2022.01014

Liang Zhang, Weiwei Xu, Hongxia Jiang, Jianqun Liu

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引用次数: 2

摘要

由于大环多胺生物碱具有抗肿瘤、抗炎、抗阿尔茨海默病和抗寄生虫等显著的药理活性，人们对其产生了浓厚的兴趣。雷公藤是一种应用广泛的中药，含有丰富的生物碱，其中包括大环多胺生物碱。然而，到目前为止，对雷公藤大环亚精胺生物碱的研究还很少。本文采用三种已知的大环亚精胺生物碱——雷公藤、西拉本嗪和西拉辛，成功地建立了一种简单灵敏的高效液相色谱法同时测定雷公藤根、茎、叶中大环亚精胺生物碱的含量。

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A simple and sensitive HPLC method for simultaneous quantification of macrocyclic spermidine alkaloids in root, stem and leaf of Tripterygium wilfordii

There has been a lively interest on macrocyclic polyamine alkaloids due to their remarkable pharmacological activities such as anti-tumor, anti-inflammatory, anti-Alzheimer's disease and anti-parasitic. Tripterygium wilfordii is a widely used traditional Chinese medicine, which is abundant in alkaloids including macrocyclic polyamine alkaloids. However, there are rarely studies on macrocyclic spermidine alkaloids of T. wilfordii so far. In this article, we use three known macrocyclic spermidine alkaloids celafurine, celabenzine and celacinnine, and successfully develop a simple and sensitive HPLC method for simultaneous quantification of macrocyclic spermidine alkaloids in root, stem and leaf of T. wilfordii.

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来源期刊

Acta Chromatographica 化学-分析化学

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

2.3 months

期刊介绍： Acta Chromatographica Open Access Acta Chromatographica publishes peer-reviewed scientific articles on every field of chromatography, including theory of chromatography; progress in synthesis and characterization of new stationary phases; chromatography of organic, inorganic and complex compounds; enantioseparation and chromatography of chiral compounds; applications of chromatography in biology, pharmacy, medicine, and food analysis; environmental applications of chromatography; analytical and physico-chemical aspects of sample preparation for chromatography; hyphenated and combined techniques; chemometrics and its applications in separation science.