Talipexole变异作为新的多巴胺D2和D3受体配体

IF 3.597 Q2 Pharmacology, Toxicology and Pharmaceutics

MedChemComm Pub Date : 2019-11-13 DOI:10.1039/c9md00379g

Lars Stank, Annika Frank, S. Hagenow, H. Stark

引用次数: 2

摘要

我们将5，6，7，8-四氢-4H-噻唑偶氮zepine支架与苯基哌嗪药效团连接，以产生比特多巴胺受体配体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Talipexole variations as novel bitopic dopamine D2 and D3 receptor ligands

We linked 5,6,7,8-tetrahydro-4H-thiazoloazepine scaffolds with phenylpiperazine pharmacophores to generate bitopic dopamine receptor ligands.

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来源期刊

MedChemComm BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2.2 months

期刊介绍： Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry. In 2020, MedChemComm will change its name to RSC Medicinal Chemistry. Issue 12, 2019 will be the last issue as MedChemComm.