啮齿动物硬膜外脊髓刺激引起的坐骨神经激活

Bioelectronics in medicine Pub Date : 2019-01-01 Epub Date: 2019-10-04 DOI:10.2217/bem-2019-0020
Narendra Bhadra, Tina Vrabec, Kevin Kilgore, Niloy Bhadra
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引用次数: 0

摘要

目的:验证在啮齿类动物模型中使用运动激活阈值(MoT)来滴定脊髓刺激的刺激幅度。方法:我们记录了10只植入硬膜外电极的Sprague-Dawley大鼠的MoT和坐骨复合动作电位阈值。将强度-持续时间曲线拟合到阈值。结果:MoT和坐骨神经复合动作电位的激活阈值顺序相同。结论:啮齿类动物脊柱中许多穿过背柱的有髓鞘大纤维在与MoT相似的电流水平下被激活。啮齿类动物的硬膜外刺激需要以接近MoT的振幅来激活这些轴突。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Activation of the sciatic nerve evoked during epidural spinal cord stimulation in rodents.

Aim: To validate the use of motor activation thresholds (MoT) to titrate stimulation amplitudes for spinal cord stimulation in rodent models.

Methods: We recorded thresholds for MoT and sciatic compound action potentials in ten Sprague-Dawley rats implanted with epidural electrodes. Strength duration curves were fitted to the threshold values.

Results: Activation thresholds were in the same order for both MoT and sciatic compound action potentials.

Conclusion: Many of the large, myelinated fibers traversing the dorsal columns in the rodent spine are activated at similar current levels to MoT. Epidural stimulation in rodents needs to be applied at amplitudes close to MoT to activate these axons.

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