用于Boswellia seratta递送的聚合物药物递送系统（PDDS）的开发与评价

IF 0.6 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materiale Plastice Pub Date : 2022-07-01 DOI:10.37358/mp.22.2.5583

Jebarani Joshua David, R. Kandasamy, Sirshendu Chatterjee

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引用次数: 0

摘要

Boswellia seratta（BS）具有抗炎和抗关节炎活性，是治疗类风湿性关节炎（RA）的最佳草药。通过口服药物递送系统递送BS是有效的，因为它在胃肠道内被酶降解。在本文中，我们开发了一种用于递送BS的胃滞留方法，以避免高肝首过代谢，并根据药物递送特性优化了口腔贴片。采用溶剂浇铸法制备了7种不同配方的BS口腔膜，分别使用粘黏聚合物、聚乙烯醇（PVA）和羧甲基纤维素钠（SCMC）。这些药物配方可以表示为多氯联苯。通过各种物理化学性质和表征研究对制备的薄膜进行了评价。从七种贴片的理化性质、体外和离体研究结果来看，PCB5具有较好的释药特性。FT-IR和XRD表征研究进一步证实了这一点。此外，使用方差分析（ANOVA）对数据进行统计分析。

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Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta

Boswellia seratta (BS) is the best herbal medicine to treat Rheumatoid Arthritis (RA), due to its anti-inflammatory and anti-arthritic activity. Delivering BS through an oral drug delivery system has been in effective, because of its enzymatic degradation within the Gastro-Intestinal (GI) tract. In this paper, we develop a gastro retentive approach for delivering BS to avoid high hepatic ﬁrst pass metabolism and optimized buccal patch based on the drug delivery characteristics. There are seven different formulated buccal films of BS that were prepared by the solvent casting method, using mucoadhesive polymers, Poly Vinyl Alcohol (PVA), and Sodium Carboxy Methyl Cellulose (SCMC). These with drug formulation can be represented as PCB. The prepared films were evaluated by various physicochemical properties and characterization studies. Results obtained from physico-chemical properties, in-vitro and ex-vivo studies among all seven patches, PCB5 shows better drug-releasing characteristics. This was further confirmed by FT-IR and XRD characterization studies. Also, the data was statistically analysed using Analysis of Variance (ANOVA).

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来源期刊

Materiale Plastice MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

1.40

自引率

25.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Materiale Plastice, abbreviated as Mater. Plast., publishes original scientific papers or guest reviews on topics of great interest. The Journal does not publish memos, technical reports or non-original papers (that are a compiling of literature data) or papers that have been already published in other national or foreign Journal.