Metabolic Effects of Electromagnetiс EHF Radiation and Ozone Therapy in the Engraftment of the Skin Flap

The aim of this study was to evaluate the effect of ROS on the intensity of oxidative and energy metabolism in the blood of rats with an operational model of ischemia of the dorsal skin flap in vivo. Our studies have allowed us to establish that the modeling of an extensive skin defect is accompanied by pronounced shifts in oxidative metabolism in the blood plasma of animals. At the same time, in the absence of pathogenetic treatment, signs of oxidative stress are formed, including the intensification of free radical processes and the inhibition of general antioxidant activity in combination with the accumulation of an increased amount of lipoperoxidation products (in particular, malondialdehyde). Conducting experimental therapy with the introduction of ozone or treatment with electromagnetic radiation of the EHF band allows partially compensating for these metabolic disorders, however, the most optimal option is a combination of these factors within a single scheme. It should be noted that the results obtained are of great applied importance for the creation of innovative technologies for the complex medical rehabilitation of orthopedic-traumatological patients as a tool for influencing reparative processes in the lesion to restore and maintain tissue structures.