姜黄素的生物转化及其类似物的构效关系综述

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biocatalysis and Biotransformation Pub Date : 2022-05-11 DOI:10.1080/10242422.2022.2073227

N. Aminudin, Nurul Aqilah Amran, Zaima Azira Zainal Abidin, D. Susanti

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引用次数: 2

摘要

摘要姜黄素因其抗氧化、抗菌、抗癌和抗炎等药理特性而广受赞誉。姜黄素的水溶性、生物利用度和细胞摄取能力较差，阻碍了其在人体内发挥最大药理作用的能力。姜黄素类似物的合成可以通过生物转化来增强其性质。更绿色、更简单、更高的选择性和特异性使生物转化成为制备姜黄素类似物用于药物设计的结构-活性关系（SAR）研究的替代方法。这项工作系统地综述了利用真菌、肠道微生物群和酶对姜黄素的生物转化。还强调了姜黄素及其类似物的几种生物活性的SAR研究。图形摘要

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Biotransformation of curcumin and structure–activity relationship (SAR) of its analogues: A systematic review

Abstract Curcumin has been widely acclaimed for several pharmacological properties, such as antioxidant, antimicrobial, anticancer, and anti-inflammation. Curcumin’s poor aqueous solubility, bioavailability, and cellular uptake hamper its ability to display maximum pharmacological effect in the human body. Synthesis of curcumin analogues to enhance its properties can be achieved through biotransformation. Greener, simpler, and higher selectivity and specificity make biotransformation an alternative approach when preparing curcumin analogues for the structure–activity relationship (SAR) study intended for drug design. This work systematically reviews the biotransformation of curcumin by utilizing fungi, gut microbiota, and enzymes. The SAR study of curcumin and its analogues for several bioactivities is also highlighted. Graphical Abstract

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来源期刊

Biocatalysis and Biotransformation 生物-生化与分子生物学

CiteScore

4.40

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： Biocatalysis and Biotransformation publishes high quality research on the application of biological catalysts for the synthesis, interconversion or degradation of chemical species. Papers are published in the areas of: Mechanistic principles Kinetics and thermodynamics of biocatalytic processes Chemical or genetic modification of biocatalysts Developments in biocatalyst''s immobilization Activity and stability of biocatalysts in non-aqueous and multi-phasic environments, including the design of large scale biocatalytic processes Biomimetic systems Environmental applications of biocatalysis Metabolic engineering Types of articles published are; full-length original research articles, reviews, short communications on the application of biotransformations, and preliminary reports of novel catalytic activities.