生酮饮食在神经系统-脑癌和其他神经系统疾病中的多重作用

Jocelyn L. Tan-Shalaby, Moustafa Khalifa, Abdullah S. Binsaeedu
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引用次数: 0

摘要

生酮饮食(KD)作为一种快速减肥的方法,目前在非专业媒体上广为人知。然而,KD并不是一个新的医学概念。KD在20世纪初被用于控制癫痫发作。然而,随着我们开发出更有效的药物,我们使用KD的次数越来越少,直到20世纪80年代它变得几乎不为人所知。与禁食的影响类似,KD导致酮的产生,作为葡萄糖的替代能源。因此,KD具有许多有益的代谢作用,如改善免疫反应、调节信号转导、炎症途径和神经传递。越来越多的证据表明KD可用于治疗各种疾病,如线粒体疾病、代谢紊乱,甚至癌症。从神经学的角度来看,KD可能对多发性硬化症、创伤性脑损伤、痴呆症和中风有治疗作用。这篇简短叙述性综述的目的是概述文献中关于KD巨大潜力的当前研究,作为涵盖多种神经疾病的综合神经治疗计划的一部分,如癫痫持续状态、创伤性脑损伤、神经退行性疾病、自身免疫性疾病、神经病变和癌症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Multifaceted Roles of Ketogenic Diets in Neurology-Brain Cancers and Other Neurologic Diseases
The ketogenic diet (KD) is currently well known in the lay media as a quick way to lose weight. However, the KD is not a new medical concept. The KD was used in the early 1900s to control seizures. However, as we developed more effective pharmacological agents, we used the KD less until it became practically obscure by the 1980s. Similar to the effects of fasting, the KD leads to the production of ketones as an alternative energy source to glucose. Therefore, the KD has many beneficial metabolic effects, such as an improved immune response, regulation of signal transduction, inflammatory pathways, and neurotransmission. There is growing evidence that KD can be used in the management of various disorders, such as mitochondrial diseases, metabolic disorders, and even cancer. From a neurological standpoint, the KD may have therapeutic benefits in multiple sclerosis, traumatic brain injury, dementia, and stroke. The purpose of this brief narrative review is to outline the current research in the literature on the great potential of the KD as part of a comprehensive neurological treatment plan covering multiple neurological disorders such as status epilepticus, traumatic brain injuries, neurodegenerative diseases, autoimmune disorders, neuropathies, and cancers.
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