烷氧基苯基氨基甲酸酯麻醉活性的统计研究

Q4 Agricultural and Biological Sciences

Nova Biotechnologica et Chimica Pub Date : 2022-01-13 DOI:10.36547/nbc.1368

T. Ďurčeková, J. Mocák, J. Lehotay, J. Čižmárik

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引用次数: 0

摘要

采用多种化学计量技术对113种烷氧基苯基氨基甲酸吗啉乙酯、哌啶乙酯、哌啶基丙基和氮杂苯乙酯衍生物的麻醉活性进行了表征。表面麻醉活性A和渗透麻醉活性B与亲脂性（用HPLC保留因子的对数logk表示）、侧烷氧基链的长度（用碳原子数n表示）、摩尔质量M以及酯类型相关。主成分分析和聚类分析用于预测两种类型的烷氧基苯基氨基甲酸酯的麻醉活性。

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Study of anaesthetical activity of alkoxyphenylcarbamic acid esters using statistical methods

Anaesthetical activity of 113 morpholinoethyl-, piperidinoethyl-, piperidinopropyl- and azepanoethyl- ester derivatives of alkoxyphenylcarbamic acid was characterized by several chemometrical techniques. The surface anaesthetical activity, A, and the infiltration anaesthetical activity, B, were correlated to lipophilicity, (expressed by the logarithm of the HPLC retention factor, log k), the length of the side alkoxy chain (represented by the number n of carbon atoms), molar mass M as well as the ester type. Principal component analysis and cluster analysis were used for predicting both types of the anaesthetic activity of the alkoxyphenylcarbamic acid esters.

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来源期刊

Nova Biotechnologica et Chimica Agricultural and Biological Sciences-Food Science

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

24 weeks